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The hydrogen sulfide donor, Lawesson’s reagent, prevents alendronate-induced ga...
Nicolau, Lucas Antonio Duarte; Silva, R.O.; Damasceno, Samara Rodrigues Bonfim; Carvalho, N.S.; Costa, N.R.D.; Aragão, Karoline Sabóia; Barbosa, A.L.R.Our objective was to investigate the protective effect of Lawesson’s reagent, an H2S donor, against alendronate (ALD)-induced gastric damage in rats. Rats were pretreated with saline or Lawesson’s reagent (3, 9, or 27 mmol/kg, po) once daily for 4 days. After 30 min, gastric damage was induced by ALD (30 mg/kg) administration by gavage. On the last day of treatment, the animals were killed 4 h after ALD adminis...
Date: 2014
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Origin: Oasisbr