5 documents found, page 1 of 1
Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus ...
Nicolau, Lucas Antonio Duarte; Carvalho, Nathalia S.; Pacífico, Dvison M.; Lucetti, Larisse T.; Aragão, Karoline Sabóia; Véras, Leiz M.C.Objective This study aimed to investigate the protective effect of epiisopiloturine hydrochloride (EPI), an imidazole alkaloid, on NAP-induced gastrointestinal damage in rats. Methods Initially, rats were pretreated with 0.5% carboxymethylcellulose (vehicle) or EPI (3, 10 and 30 mg/kg, p.o. or i.p., groups 3–5, respectively) twice daily, for 2 days. After 1 h, NAP (80 mg/kg, p.o.) was given. The control group r...
A sulfated-polysaccharide fraction from seaweed gracilaria birdiae prevents nap...
Silva, Renan O.; Santana, Ana Paula M.; Carvalho, Nathalia S.; Bezerra, Talita S.; Oliveira, Camila B.; Damasceno, Samara Rodrigues BonfimAbstract: Red seaweeds synthesize a great variety of sulfated galactans. Sulfated polysaccharides (PLSs) from seaweed are comprised of substances with pharmaceutical and biomedical potential. The aim of the present study was to evaluate the protective effect of the PLS fraction extracted from the seaweed Gracilaria birdiae in rats with naproxen-induced gastrointestinal damage. Male Wistar rats were pretreated w...
Carvacryl acetate, a derivative of carvacrol, reduces nociceptive and inflammat...
Damasceno, Samara Rodrigues Bonfim; Oliveira, Francisco Rodrigo A.M.; Carvalho, Nathalia S.; Brito, Camila F.C.; Silva, Irismara S.Aims: The present study aimed to investigate the potential anti-inflammatory and anti-nociceptive effects of carvacryl acetate, a derivative of carvacrol, in mice. Main methods: The anti-inflammatory activity was evaluated using various phlogistic agents that induce paw edema, peritonitis model, myeloperoxidase (MPO) activity, pro and anti-inflammatory cytokine levels. Evaluation of antinociceptive activity was...
Anti-inflammatory and antinociceptive activity of epiisopiloturine, an imidazol...
Silva, Valdelânia G.; Silva, Renan O.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Prudêncio, Rafael S.; Aragão, Karoline SabóiaThe aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus. The anti-inflammatory activity of 1 was evaluated using several agents that induce paw edema and peritonitis in Swiss mice. Paw tissue and peritoneal fluid samples were obtained to determine myeloperoxidase (MPO) activity or ...
Phytol, a diterpene alcohol, inhibits the inflammatory response by reducing cyt...
Silva, Renan O.; Sousa, Francisca Beatriz M.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Silva, Valdelânia G.Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and oxidative stress. The anti-inflammatory activities of phytol were assessed by measuring paw edema...