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The impact of sequence length and number of sequences on promoter prediction pe...
Carvalho, Sávio Gonçalves; Cota, Renata Guerra de Sá; Merschmann, Luiz Henrique de CamposBackground: The advent of rapid evolution on sequencing capacity of new genomes has evidenced the need for data analysis automation aiming at speeding up the genomic annotation process and reducing its cost. Given that one important step for functional genomic annotation is the promoter identification, several studies have been taken in order to propose computational approaches to predict promoters. Different c...
Genome-wide identification of novel microRNAs and their target genes in the hum...
Gomes, Matheus de Souza; Muniyappa, Mohan Kumar; Carvalho, Sávio Gonçalves; Cota, Renata Guerra de Sá; Spillane, CharlesMature microRNAs (miRNAs) are small, non-coding regulatory RNAs which can elicit post-transcriptional repression of mRNA levels of target genes. Here, we report the identification of 67 mature and 42 precursor miRNAs in the Schistosoma mansoni parasite. The evolutionarily conserved S. mansoni miRNAs consisted of 26 precursor miRNAs and 35 mature miRNAs, while we identified 16 precursor miRNAs and 32 mature miRN...