36 documents found, page 1 of 4
Generation of an obese diabetic mouse model upon conditional Atrx disruption
Gaspar, Tiago Bordeira; Jesus, Tito Teles; Azevedo, Maria Teresa; Macedo, Sofia; Soares, Mariana Alves; Martins, Rui Sousa; Leite, Rúben; Rodrigues, LiaATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homo...
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, Nuno; Sousa, Susana R.; Padrão, Tatiana; Carvalho, Ângela; Lucas, Raquel; Canadas, Raphael F.; Lavrador, Catarina; Alexandre, NunoThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, Nuno; Sousa, Susana; Gärtner, Fátima; Monteiro, Fernando; Gutierres, Manuel; Lavrador, CatarinaThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs a...
Nunes, Francisco Cortez; Mateus, Teresa Letra; Taillieu, Emily; Teixeira, Sílvia; Carolino, Nuno; Rema, Alexandra; Bruyckere, Sofie De; Gärtner, FátimaBesides Helicobacter pylori, a Gram-negative bacterium that may cause gastric disorders in humans, non-Helicobacter pylori helicobacters (NHPH) may also colonize the stomach of humans and animals. In pigs, H. suis can induce gastritis and may play a role in gastric ulcer disease, possibly in association with Fusobacterium gastrosuis. In the present study, gastric samples from 71 slaughtered pigs and 14 hunted f...
Biotinylated polymer-ruthenium conjugates: in vitro and in vivo studies in a tr...
Côrte-Real, Leonor; Brás, Ana Rita; Pilon, Adhan; Mendes, Nuno Miguel Morais; Ribeiro, Ana Sofia; Martins, Tiago D.; Farinha, José Paulo S.The need for new therapeutic approaches for triple-negative breast cancer is a clinically relevant problem that needs to be solved. Using a multi-targeting approach to enhance cancer cell uptake, we synthesized a new family of ruthenium(II) organometallic complexes envisaging simultaneous active and passive targeting, using biotin and polylactide (PLA), respectively. All compounds with the general formula, [Ru(...
Exercise performed during pregnancy positively modulates liver metabolism and p...
Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, Rossana; Fernandes, RuiGestational diabetes mellitus (GDM) is associated with a high-risk for metabolic complications in offspring. However, exercise is recognized as a non-pharmacological strategy against metabolic disorders and is recommended in GDM treatment. This study aimed to investigate whether gestational exercise (GE) could modulate maternal high-fat high-sucrose (HFHS) diet-related hepatic metabolic and mitochondrial outcom...
Molecular detection of human pathogenic gastric helicobacter species in wild ra...
Nunes, Francisco Cortez; Mateus, Teresa Letra; Teixeira, Sílvia; Barradas, Patrícia F.; Gärtner, Fátima; Haesebrouck, Freddy; Amorim, IrinaWildlife plays a major role in the maintenance and transmission of multihost pathogens. Several Helicobacter spp. have been described to have zoonotic potential; thus, human, domestic and wild animal interactions deserve more attention. In this study, the presence of the DNA of human pathogenic gastric Helicobacter species was determined in gastric samples collected from wild rabbits and wild quails during the ...
Presence of Helicobacter pylori and H. suis DNA in free-range wild boars
Nunes, Francisco Cortez; Mateus, Teresa Letra; Teixeira, Sílvia; Barradas, Patrícia; Witte, Chloë de; Haesebrouck, Freddy; Amorim, IrinaHelicobacter pylori (H. pylori) is a Gram-negative bacterium that infects half of the human population worldwide, causing gastric disorders, such as chronic gastritis, gastric or duodenal ulcers, and gastric malignancies. Helicobacter suis (H. suis) is mainly associated with pigs, but can also colonize the stomach of humans, resulting in gastric pathologies. In pigs, H. suis can induce gastritis and seems to pl...
Molecular detection of Rickettsia spp. in ticks and fleas collected from rescue...
Barradas, Patrícia F.; Mesquita, João R.; Mateus, Teresa L.; Ferreira, Paula; Amorim, Irina; Gärtner, FátimaHedgehogs (e.g., Erinaceus europaeus, E. roumanicus) are wild mammals that frequently are observed near residential areas. The aim of this study was to investigate ticks and feas collected from European hedgehogs in Portugal and to evaluate the prevalence of Rickettsia in those ectoparasites. Ticks and feas were identifed by morphological and molecular methods, and molecular detection by PCR and genotypic chara...
Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...
Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Pereira, Susana; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, RossanaMaternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development of metabol...