2 documents found, page 1 of 1
NFIXing Cancer: The Role of NFIX in Oxidative Stress Response and Cell Fate
Ribeiro, Vanessa; Martins, Susana G.; Lopes, Ana Sofia; Thorsteinsdottir, Solveig; Zilhão, Rita; Carlos, Ana RitaNFIX, a member of the nuclear factor I (NFI) family of transcription factors, is known to be involved in muscle and central nervous system embryonic development. However, its expression in adults is limited. Similar to other developmental transcription factors, NFIX has been found to be altered in tumors, often promoting pro-tumorigenic functions, such as leading to proliferation, differentiation, and migration...
Linking Oxidative Stress and DNA Damage to Changes in the Expression of Extrace...
Martins, Susana G.; Zilhão, Rita; Thorsteinsdottir, Solveig; Carlos, Ana RitaCells are subjected to endogenous [e.g., reactive oxygen species (ROS), replication stress] and exogenous insults (e.g., UV light, ionizing radiation, and certain chemicals), which can affect the synthesis and/or stability of different macromolecules required for cell and tissue function. Oxidative stress, caused by excess ROS, and DNA damage, triggered in response to different sources, are countered and resolv...