3 documents found, page 1 of 1
In vitro and in silico evaluation of the schistosomicidal activity of eugenol d...
Souza,Isabella Maria Monteiro de; Novaes,Romulo Dias; Gonçalves,Reggiani Vilela; Fialho,Felipe Leonardo Bley; Carvalho,Diogo TeixeiraAbstract Background Eugenol shows both antibacterial and antiparasitic activities, suggesting that it might be evaluated as an option for the treatment of praziquantel-resistant schistosome. Methods The in vitro activities of three eugenol derivatives (FB1, FB4 and FB9) on adult worms from Schistosoma mansoni were examined by fluorescence and scanning electron microscopy to analyze effects on the excretory syst...
Síntese e avaliação preliminar da atividade antibacteriana e antifúngica de der...
Cachiba,Thomas Haruo; Carvalho,Bruno Demartini; Carvalho,Diogo Teixeira; Cusinato,Marina; Prado,Clara Gavião; Dias,Amanda Latercia TranchesWe describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC50 values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with...
Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosi...
Butera,Anna Paola; Souza Filho,José Dias de; Carvalho,Diogo Teixeira; Figueiredo,Rute Cunha; Faria,Luiz Carlos Alves de; Nunes,Maria AngélicaWe report herein the synthesis of some beta-D-galactopyranosylamine and beta-lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in a hemagglutination inhibitory activity assay. D-Galactose and lactose were used as reference compounds. The beta-lactosylamine amides and sulfonamides were...