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Antiproliferative potential of solidagenone isolated of Solidago chilensis
Gomes,Denise B.; Zanchet,Barbara; Locateli,Gelvani; Benvenutti,Régis C.; Vechia,Cristian A. Dalla; Schönell,Amanda P.; Diel,Kriptsan A.P.ABSTRACT Plants are considered among the main sources of biologically active chemicals. The species Solidago chilensis Meyen, Asteraceae, is native to the southern parts of South America, where the aerial parts of the plant are commonly used for the treatment of inflammatory conditions. However, the effects of S. chilensis on human cancer cells remain to be elucidated. In this study, we evaluated the antiprolif...
LUCLARICIN, A NEW LIGNAN FROM PHYLLANTHUS ACUMINATUS
Duarte,Susyanne L. F.; Nascimento,Yuri M.; Madeiro,Sara A. L.; Costa,Vicente C. O.; Agra,Maria F.; Sobral,Marianna V.; Braz-Filho,RaimundoThe secondary metabolites of the aerial parts of Phyllanthus acuminatus Vahl (Phyllanthaceae) and the biological activity of one of them were characterized in this study. This chemical investigation led to isolation of two lignans, luclaricin (1), a new arylnaphtalene-typelignan, and justicidin B (2). The structures of isolated compounds were determined based on 1D and 2D-NMR, HRESIMS and IR. The cytotoxic acti...
Antiproliferative effects of pinostrobin and 5,6-dehydrokavain isolated from le...
Roman Junior,Walter A.; Gomes,Denise B.; Zanchet,Barbara; Schönell,Amanda P.; Diel,Kriptsan A.P.; Banzato,Thais P.; Ruiz,Ana L.T.G.; Carvalho,João E.Abstract Natural products are a major source of drugs for the treatment of cancer. The species Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm, Zingiberaceae, is widely distributed in Brazil where it is known as “colônia”. The leaves are commonly used in the treatment of hypertension and dyspepsia, however, the effects of A. zerumbet extracts and isolated substances on human cancer cells remain to be elucidated. ...
Comparison of Standardized Dichloromethane with Aqueous Pterodon pubescens Bent...
Grando,Rogério; Souza,Vanessa H.; Monteiro,Karin M.; Sousa,Ilza M. O.; Queiroz,Nubia C. A.; Carvalho,João E.; Spindola,Humberto M.; Foglio,Mary A.Pterodon pubescens Benth., popularly known as "sucupira", is traditionally used as pain healing agent for many inflammatory diseases. The present study evaluated the in vivo antinociceptive and anti-inflammatory properties of sucupira's fruit dicloromethane extract (Pp) compared to the aqueous extract (Ppa) traditionally used in folk medicine. Extracts' chemical characterization was performed by gas chromatogra...
Synthesis, in vitro Antiproliferative and Anti-Mycobacterium tuberculosis Activ...
Moreira,Flora M. F.; Croda,Julio; Sarragiotto,Maria H.; Foglio,Mary A.; Ruiz,Ana L. T. G.; Carvalho,João E.; Formagio,Anelise S. N.A series of β-carboline derivatives with amino or guanidinium were synthesized and evaluated in vitro against anti-Mycobacterium tuberculosis and for antiproliferative activities against nine human cancer cell lines. The compounds 1-(4-hydroxyphenyl)-3-carboxamide(ethylamine) β-carboline (24.9 µg mL-1) and 1-(4-methoxyphenyl)-3-carboxamide(ethylamine) β-carboline (26.9 µg mL-1) were the most active against M. T...
Estudo químico e atividades antiproliferativa, tripanocida e leishmanicida de M...
Almeida,Thiago L. de; Monteiro,Josiane A.; Lopes,Greice K. P.; Chiavelli,Lucas U. R.; Santin,Silvana M. de O.; Silva,Cleuza C. da; Kaplum,VanessaThe chemical study of the orchid Maxillaria picta resulted in the isolation of the bioactive stilbenes phoyunbene B and phoyunbene C, in addition to four phenolic acids, one xanthone, steroidal compounds and two triterpenes. Crude extract, fractions, subfractions and the isolated xanthone were evaluated for anticancer activity against human tumor cell lines and against evolutionary forms of T. cruzi and L. amaz...
Antiproliferative activity of methanol extracts of four species of Croton on di...
Savietto,Jóice P.; Furlan,Cláudia M.; Motta,Lucimar B.; Salatino,Maria Luiza F.; Carvalho,João E.; Ruiz,Ana Lucia T. G.; Salatino,AntonioSeveral species of Croton have been described with biological activities, mainly due to diterpenes, alkaloids and/or other secondary metabolites. These activities account for the traditional use of Croton species to treat certain diseases in South America, Asia and Western Africa. The crude methanol extracts obtained from leaves and steam bark of Croton dichrous Müll. Arg., C. erythroxyloides Baill., C. myriant...
Capacidade antioxidante e triagem farmacológica de extratos brutos de folhas de...
Pompeu,Darly R.; Rogez,Hervé; Monteiro,Karin M.; Tinti,Sirlene V.; Carvalho,João E.Com o objetivo de avaliar o efeito de duas espécies amazônicas em doenças relacionadas aos processos de oxidação, determinou-se a capacidade antioxidante (método Oxygen Radical Absorbance Capacity), o teor de polifenóis totais (método Folin-Ciocalteu - PT), bem como os efeitos farmacológicos in vitro (efeito antiproliferativo) e in vivo (antinociceptivo, antiinflamatório, antiulcerogênico) dos extratos hidroalc...
Farmacologia e Toxicologia de Peumus boldus e Baccharis genistelloides
Ruiz,Ana Lúcia T. G.; Taffarello,Denise; Souza,Vanessa H. S.; Carvalho,João E.Um grande número de espécies com uso medicinal tradicional ainda continua sem comprovação da eficácia e da segurança de seu uso. Este artigo apresenta uma pequena revisão sobre os trabalhos publicados com boldo (Peumus boldus) e carqueja (Baccharis genistelloides). Os estudos farmacológicos realizados com P. boldus e B. genistelloides comprovam várias das atividades atribuídas popularmente a esses chás, além de...
Effect of Artemisia annua L. leaves essential oil and ethanol extract on behavi...
Perazzo,Fabio F.; Lima,Leonardo M.; Maistro,Edson Luis; Carvalho,João E.; Rehder,Vera L. G.; Carvalho,José C. T.Artemisia annua has been used as a traditional plant for the treatment of malaria and fever in China because of the presence of its active compound, artemisinin. The present study evaluated the central activity of the essential oil and the crude ethanol extract of A. annua L. in animals as a part of a psychopharmacological screening of this plant. The extract was prepared in ethanol (AEE) and the essential oil ...