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Chemical Composition and Cytotoxic Activity of the Root Essential Oil from Jatr...
Silva,Celia E. L. da; Minguzzi,Sandro; Silva,Rogério C. L. da; Matos,Maria F. C.; Tofoli,Danilo; Carvalho,João E. de; Ruiz,Ana L. T. G.The essential oil of roots of Jatropha ribifolia, obtained by hydrodistillation, was characterized in terms of its chemical composition by chromatographic method with flame ionization detection (GC-FID) and gas chromatography coupled to electron ionization mass spectrometry (GC-MS). The analyses and identification pointed by mass fragmentation pattern and retention index revealed the presence of 49 compounds, r...
Prenylated flavonoids from roots of Dahlstedtia glaziovii (Fabaceae)
Canzi,Edione F.; Marques,Francisco A.; Teixeira,Sirlei D.; Tozzi,Ana Maria G. A.; Silva,Marcos J.; Duarte,Renata Maria T.; Duarte,Marta Cristina T.A phytochemical study of roots of Dahlstedtia glaziovii (Fabaceae) furnished a new dibenzoylmethane (glaziovione), along with eighteen known compounds. Their structures were determined through 1D and 2D nuclear magnetic resonance (NMR) (heteronuclear single quantum coherence, HSQC, and heteronuclear multiple bond correlation, HMBC) and high-resolution mass spectrometry (HRMS) spectral analyses. The antiprolifer...
Isolation, structural identification and cytotoxic activity of hexanic extract,...
Fernandes,Elaine de S.; Rodrigues,Fátima A.; Tófoli,Danilo; Imamura,Paulo M.; Carvalho,João E. de; Ruiz,Ana L. T. G.; Foglio,Mary A.; Minguzzi,SandroThe cytotoxicity of a hexanic fraction produced from the ethanolic crude extract, obtained from Jatropha ribifolia (Pohl) Baill, Euphorbiaceae, roots was evaluated against ten human cancer cell lines (MCF-7, NCI-ADR/RES, OVCAR-3, PC-3, HT-29, NCI-H460,786-O, UACC-62, K-562, U251) compared with doxorrubicine as positive control. Compounds jatrophone and cyperenoic acid were isolated from the hexanic extract and ...
Pterodon pubescens benth: stability study of microencapsulated extract and isol...
Servat,Leila; Spindola,Humberto M.; Rodrigues,Rodney A. F.; Sousa,Ilza M. O.; Ruiz,Ana L. T. G.; Carvalho,João E. de; Foglio,Mary A.Pterodon pubescens Benth. (Pp) seeds, commercially available in Brazil, are used in folk medicine in anti-inflammatory, analgesic, and anti-rheumatic preparations. The present study demonstrated the antinociceptive properties of isomers 6α-hydroxy-7β-acetoxy-vouacapan-17β-oate methyl ester and 6α-acetoxy-7β-hydroxy-vouacapan-17β-oate methyl ester (C1), isolated from (Pp), employing different experimental models...
Constituents and antiproliferative activity of extracts from leaves of Croton m...
Motta,Lucimar B.; Furlan,Cláudia M.; Santos,Deborah Y. A. C.; Salatino,Maria L. F.; Duarte-Almeida,Joaquim M.; Negri,Giuseppina; Carvalho,João E. deCroton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/RES (drug resistant ovar...
Synthesis, antitumor and antimicrobial activity of novel 1-substituted phenyl-3...
Savariz,Franciele C.; Formagio,Anelise S. N.; Barbosa,Valéria A.; Foglio,Mary Ann; Carvalho,João E. de; Duarte,Marta C. T.; Dias Filho,Benedito P.With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities o...
Furanoditerpenes from Pterodon pubescens benth with selective in vitro anticanc...
Spindola,Humberto M.; Carvalho,João E. de; Ruiz,Ana Lúcia T. G.; Rodrigues,Rodney A. F.; Denny,Carina; Sousa,Ilza M. de Oliveira; Tamashiro,Jorge Y.Activity guided fractionation of Pterodon pubescens Benth. methylene chloride-soluble fraction afforded novel 6α-acetoxi 7β-hydroxy-vouacapan 1 and four known diterpene furans 2, 3, 4, 5. The compounds were evaluated for in vitro cytotoxic activities against human normal cells and tumour cell lines UACC-62 (melanoma), MCF-7 (breast), NCI-H460 (lung, non-small cells), OVCAR-03 (ovarian), PC-3 (prostate), HT-29 (...
Synthesis and antiproliferative activity of novel limonene derivatives with a s...
Figueiredo,Isis M.; Santos,Luciane V. dos; Costa,Willian F. da; Carvalho,João E. de; Silva,Cleuza C. da; Sacoman,Juliana L.; Kohn,Luciana K.A series of R-(+)-limonene derivatives bearing a substituted thiourea moiety (3-13) and five S-methyl analogs (14-18) were synthesized and evaluated for their in vitro antiproliferative activity against human cancer cell lines. Compounds bearing aromatic substituents (3-6) exhibit cytotastic activity in the full panel of cell lines tested, with GI50 values in the range of 2.5 to 24 µmol L-1. Compounds 3, 10, 12...