42 documents found, page 1 of 5
Impact of oral hygiene in patients undergoing mechanical ventilation in the COV...
Silva,Dayane Helen Ferreira; Camargos,Júlia Hinkelmann de; Rodrigues,Jefferson Guimarães; Nogueira,Leilismara Sousa; Azevedo,Dênia Alves deSUMMARY COVID-19, caused by SARS-CoV-2, can present respiratory complications that often lead patients to depend on mechanical ventilation (MV) for several days. It is known that Pneumonia Associated with Mechanical Ventilation (PAMV) is frequent in patients who use this equipment for a long time. As a consequence of COVID-19, its prolonged use can lead to a worse prognosis for the patients. For this reason, in...
Thrombin generation and thromboelastometry tests in dogs with chronic kidney di...
Gonçalves,Daniele S.; Geraldes,Silvano S.; Duarte,Rita Carolina F.; Carvalho,Maria das Graças; Guimarães-Okamoto,Priscylla Tatiana C.ABSTRACT: Patients with chronic kidney disease (CKD) have paradoxical hemostatic potential because they have bleeding episodes but are also prone to thrombosis. Few studies have evaluated blood viscoelastic properties in dogs with kidney disease; on the other hand, hypercoagulability has been observed in these patients. It is also emphasized that the platelet function and its participation in this process have ...
Association of different biomarkers of renal function with D-dimer levels in pa...
Domingueti,Caroline Pereira; Fóscolo,Rodrigo Bastos; Dusse,Luci Maria S; Reis,Janice Sepúlveda; Carvalho,Maria das Graças; Gomes,Karina BragaABSTRACT Objective This study aimed to evaluate the association between different renal biomarkers with D-Dimer levels in diabetes mellitus (DM1) patients group classified as: low D-Dimer levels (< 318 ng/mL), which included first and second D-Dimer tertiles, and high D-Dimer levels (≥ 318 ng/mL), which included third D-Dimer tertile. Materials and methods D-Dimer and cystatin C were measured by ELISA. Creatini...
OxLDL plasma levels in patients with Alzheimer's disease
Grossi,Marina Felipe; Carvalho,Maria das Graças; Silveira,Josianne Nicácio; Gonçalves,Gisele Santos; Gomes,Karina Braga; Bicalho,Maria AparecidaABSTRACT Objective: The objective of this study was to characterize the conventional lipid profile, oxLDL levels and ApoE polymorphism in patients with Alzheimer's disease (AD) and in elderly individuals without cognitive impairment. Methods: Eighty elderly individuals were selected and the levels of oxLDL were determined using the ELISA kit, and ApoE gene polymorphism was investigated using polymerase chain re...
Apolipoprotein E and PAI-1 gene polymorphisms and no association with arterial ...
Evangelista,Fernanda Cristina G.; Rios,Danyelle R. A.; Ribeiro,Daniel D.; Carvalho,Maria das Graças; Dusse,Luci Maria S.; Mota,Ana Paula L.ABSTRACT Introduction: Arterial thrombosis is considered a multifactorial disease, resulting from the interaction of genetic and acquired risk factors. Objectives: The aim of this study was to investigate the presence of the polymorphism in inhibitor of plasminogen activator type 1 (PAI-1) and apolipoprotein E (ApoE) genes and its interactions with PAI-1 levels and lipids and apolipoprotein profiles, respective...
Thrombin generation assays for global evaluation of the hemostatic system: pers...
Duarte,Rita Carolina Figueiredo; Ferreira,Cláudia Natália; Rios,Danyelle Romana Alves; Reis,Helton José dos; Carvalho,Maria das GraçasAbstract The existing techniques to evaluate hemostasis in clinical laboratories are not sensitive enough to detect hypercoagulable and mild hypocoagulable states. Under different experimental conditions, the thrombin generation test may meet these requirements. This technique evaluates the overall balance between procoagulant and anticoagulant forces and has provided new insights in our understanding of the co...
Economy class syndrome: what is it and who are the individuals at risk?
Dusse,Luci Maria SantAna; Silva,Marcos Vinícius Ferreira; Freitas,Letícia Gonçalves; Marcolino,Milena Soriano; Carvalho,Maria das GraçasAbstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, c...
Estrogen receptor-alpha gene XbaI A > G polymorphism influences short-term c...
Chaves,Amanda Caroline Silva; Fraga,Vanessa Gomes; Guimarães,Henrique Cerqueira; Teixeira,Antonio Lucio; Barbosa,Maira TonidandelABSTRACT This prospective study aimed to evaluate the influence of the -351A/G XbaI polymorphism in the estrogen receptor-alpha (ESR-1) gene on global cognitive scores of a community sample of healthy oldest-old individuals within one year of follow up. Methods The individuals were categorized in two groups according to the presence or absence of cognitive decline. Cognitive data were related to genetic informa...
Alzheimer’s disease and cytokine IL-10 gene polymorphisms: is there an associat...
Magalhães,Carolina Antunes; Carvalho,Maria das Graças; Sousa,Lirlândia Pires de; Caramelli,Paulo; Gomes,Karina BragaABSTRACT Alzheimer’s disease (AD) is the most common form of dementia. In the last 15 years, a new theory has proposed the autoimmune mechanism as a trigger for AD. Studies on the association between AD and inflammatory biomarkers have yielded controversial results. Interleukin-10 (IL-10), an anti-inflammatory mediator, has been pointed out as one of the main cytokines associated with the occurrence of AD. More...
Evaluation of creatinine-based and cystatin C-based equations for estimation of...
Domingueti,Caroline Pereira; Fóscolo,Rodrigo Bastos; Simões e Silva,Ana Cristina; Dusse,Luci Maria S.; Reis,Janice Sepúlveda; Carvalho,Maria das GraçasABSTRACT Objective Several formulas based in different biomarkers may be used to estimate glomerular filtration rate (GRF). However, all of them have some limitations, and it is very important to evaluate their performances in different groups of patients. Therefore, we compared GFR, as estimated by creatinine-based and cystatin C-based equations, according to albuminuria, in type 1 diabetes (T1DM), in an obser...