14 documents found, page 1 of 2
Assessment of factors associated with potential drug-drug interactions in patie...
Resende,Natália Helena de; Miranda,Silvana Spíndola de; Ceccato,Maria das Graças Braga; Reis,Adriano Max Moreira; Haddad,João Paulo AmaralAbstract INTRODUCTION: The concomitant use of antituberculosis and antiretroviral drugs, as well as drugs to treat other diseases, can cause drug-drug interactions. This study aimed to describe potential drug-drug interactions (pDDI) in patients with TB and HIV/AIDS co-infection, as well as to analyze possible associated factors. METHODS: This study was performed in a reference hospital for infectious and conta...
Avaliação do desempenho dos serviços de atenção primária à saúde no controle da...
Rabelo,Juliana Veiga Costa; Navarro,Pedro Daibert de; Carvalho,Wânia da Silva; Almeida,Isabela Neves de; Oliveira,Camila Stefânie FonsecaResumo: A Organização Mundial da Saúde destaca a importância da organização e do desempenho dos serviços de saúde nas ações de controle da tuberculose. O objetivo deste estudo foi avaliar o desempenho dos serviços de atenção primaria à saúde em Belo Horizonte, Minas Gerais, Brasil, em relação às ações de controle da tuberculose nos eixos Estrutura e Processo, antes e após a utilização do instrumento validado de...
The impact of the stratification by degree of clinical severity and abandonment...
Navarro,Pedro Daibert de; Haddad,João Paulo Amaral; Rabelo,Juliana Veiga Costa; Silva,Claudia Hermínia de Lima e; Almeida,Isabela Neves deABSTRACT Objective: Evaluate the impact of the instrument of the “Stratification by Degree of Clinical Severity and Abandonment Risk of Tuberculosis Treatment” (SRTB) on the tuberculosis outcome. Methods: This study was a pragmatic clinical trial involving patients with a confirmed diagnosis of tuberculosis treated at one of the 152 primary health care units in the city of Belo Horizonte, Brazil, between May of...
Genotype®MTBDRplus and Xpert®MTB/RIF in the diagnosis of tuberculosis and resis...
Soares,Valéria Martins; Almeida,Isabela Neves de; Vater,Maria Cláudia; Alves,Suely; Figueredo,Lida Jouca de Assis; Scherer,LucieneAbstract INTRODUCTION: The present study sought to assess the mean and activity based cost (ABC) of the laboratory diagnosis for tuberculosis through the application of conventional and molecular techniques-Xpert®MTB/RIF and Genotype®MTBDRplus-in a tertiary referral hospital in Brazil. METHODS: The mean cost and ABC formed the basis for the cost analysis of the TB laboratory diagnosis. RESULTS: The mean cost an...
Cost analysis of smear microscopy and the Xpert assay for tuberculosis diagnosi...
Figueredo,Lida Jouca de Assis; Miranda,Silvana Spíndola de; Santos,Lucas Benício dos; Manso,Caroline Gontijo Gonçalves; Soares,Valéria MartinsAbstract INTRODUCTION: Rapid and accurate tuberculosis detection is critical for improving patient diagnosis and decreasing tuberculosis transmission. Molecular assays can significantly increase laboratory costs; therefore, the average time and economic impact should be evaluated before implementing a new technology. The aim of this study was to evaluate the cost and average turnaround time of smear microscopy ...
Prevalence of smoking and associated factors in people living with HIV undergoi...
Teixeira,Luciane de Souza Leal; Ceccato,Maria das Graças Braga; Carvalho,Wânia da Silva; Costa,Juliana de Oliveira; Bonolo,Palmira de FátimaABSTRACT OBJECTIVE: To estimate the prevalence of smoking and evaluate the factors associated with this outcome in people living with HIV (PLHIV). METHODS: This is a cross-sectional study of a prospective concurrent cohort of 462 individuals initiating antiretroviral therapy at three HIV/AIDS specialized services in Belo Horizonte between 2015 and 2017. The following smoking status were used: current smoker (CS...
Detection of Drug Resistant Mycobacterium Tuberculosis Strains Using Kit SIRE N...
Miranda,Silvana Spindola de; Almeida,Isabela Neves de; Mansur,Maria de Fátima Filardi Oliveira; Figueredo,Lida Jouca de Assis; Carvalho,Wânia da SilvaAbstract (1) Background: The Commercial Kit SIRE Nitratase® PlastLabor, is a drug susceptibility test kit used to detect Mycobacterium tuberculosis resistance to first-line TB treatment drugs. The present study aimed at evaluating its performance in a multicenter study. (2) Methods: To determine its accuracy, the proportion methods in Lowenstein Jensen medium or the BACTECTMMGITTM960 system was used as a gold s...
Factors associated with tuberculosis and multidrug-resistant tuberculosis in pa...
Soares,Valéria Martins; Almeida,Isabela Neves de; Figueredo,Lida Jouca de Assis; Haddad,João Paulo Amaral; Oliveira,Camila Stefanie Fonseca deABSTRACT Objective: To evaluate the risk factors for the development of tuberculosis and multidrug-resistant tuberculosis (MDR-TB) in patients treated at a tertiary referral hospital. Methods: This was a cross-sectional study based on data obtained from patients treated at the Júlia Kubitschek Hospital, located in the city of Belo Horizonte, Brazil, between October of 2012 and October of 2014. We evaluated soci...
Drug therapy problems for patients with tuberculosis and HIV/AIDS at a referenc...
Resende,Natália Helena de; Miranda,Silvana Spíndola de; Ceccato,Maria das Graças Braga; Haddad,João Paulo Amaral; Reis,Adriano Max MoreiraABSTRACT Objective: To determine the frequency of drug therapy problem in the treatment of patients with tuberculosis and HIV/AIDS. Methods: Data were obtained through a cross-sectional study conducted between September 2015 and December 2016 at a reference hospital in infectious diseases in Belo Horizonte (MG), Brazil. Sociodemographic, clinical, behavioral and pharmacotherapeutic variables were evaluated thro...
Comparative study of RFLP-IS6110 and MIRU-VNTR from Mycobacterium tuberculosis ...
Augusto,Cláudio José; Carvalho,Wânia da Silva; Almeida,Isabela Neves de; Figueiredo,Lida Jouca de Assis; Dantas,Nayanne Gama TeixeiraAbstract DNA genotyping of Mycobacterium tuberculosis has been widely applied in the understanding of disease transmission in many countries. The purpose of this study was to genotype the strains of M. tuberculosis isolated in patients with new tuberculosis (TB) cases in Minas Gerais, as well as to compare the similarity, discriminatory power, and agreement of the clusters between the IS6110 Restriction Fragmen...