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Synthesis and biological activity of sulfur compounds showing structural analog...
Santos,Edson dos A. dos; Prado,Paulo C.; Carvalho,Wanderley R. de; Lima,Ricardo V. de; Beatriz,Adilson; Lima,Dênis P. de; Hamel,Ernest; Dyba,Marzena A.We extended our previous exploration of sulfur bridges as bioisosteric replacements for atoms forming the bridge between the aromatic rings of combretastatin A-4. Employing coupling reactions between 5-iodo-1,2,3-trimethoxybenzene and substituted thiols, followed by oxidation to sulfones with m-CPBA, different locations for attaching the sulfur atom to ring A through the synthesis of nine compounds were examine...
Date: 2013
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Origin: Oasisbr