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Pericentrin-mediated SAS-6 recruitment promotes centriole assembly
Ito, Daisuke; Zitouni, Sihem; Jana, Swadhin Chandra; Duarte, Paulo; Surkont, Jaroslaw; Carvalho-Santos, Zita; Pereira-Leal, José BThe centrosome is composed of two centrioles surrounded by a microtubule-nucleating pericentriolar material (PCM). Although centrioles are known to regulate PCM assembly, it is less known whether and how the PCM contributes to centriole assembly. Here we investigate the interaction between centriole components and the PCM by taking advantage of fission yeast, which has a centriole-free, PCM-containing centrosom...
BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of...
Carvalho-Santos, Zita; Machado, Pedro; Alvarez-Martins, Inês; Gouveia, Susana M.; Jana, Swadhin C.; Duarte, Paulo; Amado, Tiago; Branco, PedroCilia and flagella are involved in a variety of processes and human diseases, including ciliopathies and sterility. Their motility is often controlled by a central microtubule (MT) pair localized within the ciliary MT-based skeleton, the axoneme. We characterized the formation of the motility apparatus in detail in Drosophila spermatogenesis. We show that assembly of the central MT pair starts prior to the meio...
Evolution: Tracing the origins of centrioles, cilia, and flagella
Carvalho-Santos, Zita; Azimzadeh, Juliette; Pereira-Leal, José B; Bettencourt-Dias, MónicaCentrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral structures; they are present in all major eukaryotic groups. Despite the conservation of their core structure, there is variability in their architecture, function, and biogenesis. Recent genomic and functional studies have provided ...
Evolution and biogenesis of microtubule-derived structures
Carvalho-Santos, ZitaDissertação apresentada para obtenção do grau de Doutor em Biologia Celular pelo Instituto de Tecnologia Química e Biológica da Universidade Nova de Lisboa; The centriole/basal body (CBB) is a Eukaryotic structure involved in a duality of functions, it can act as a microtubule organizing centre or it can nucleate the axoneme of cilia and flagella. The CBB is a widely conserved microtubule based ninefold symmetr...