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Co-inhibition of MPS-1 with BCL-2 family inhibitors enhances lung cancer cell k...

Pinto, B.; Silva, P.; Sarmento, B.; Carvalho-Tavares, J.; Bousbaa, Hassan

Background: Lung cancer is the leading cause of cancer death worldwide, posing a significant public health challenge [1]. Currently available therapies, when administered as monotherapy, have limited efficacy, high toxicity, and can lead to increased tumor resistance. Overexpression of MPS-1, a protein kinase involved in mitosis, has been observed in various types of tumors. Its inhibition is associated with ab...

Date: 2023   |   Origin: Scientific Letters
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