2 documents found, page 1 of 1
Developing robust heterotypic 3D lung cancer cultures for drug screening: preli...
Pinto, Bárbara; A. Silva, Patrícia M.; Sarmento, Bruno; Carvalho-Tavares, Juliana; Bousbaa, HassanBackground: To propel advancements in cancer treatment, it is imperative to conduct initial drug testing using in vitro models. In laboratory settings, the efficacy of most compounds is rigorously evaluated through 2D cell cultures. However, many compounds showing promise in these models fail to perform similarly in preclinical or clinical trials, prolonging the timeline for developing effective drugs for human...
Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuat...
Pinto, Barbara Fernandes; Ribeiro, Lorena Natasha Brito; Da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]; Freitas, Camila Simoes; Kraemer, LucasMade available in DSpace on 2022-04-29T08:38:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Rationale: The FDA-approved Dimethyl Fumarate (DMF) as an oral drug for Multiple Sclerosis (MS) treatment based on its immunomodulatory activities. However, it also caused severe adverse effects mainly related to the gastrointestinal system. Objective: Investigated the potential effects of solid lipid n...