16 documents found, page 1 of 2
Post-Therapy Epilepsy Prevalence in Patients with High-Grade Gliomas: a systema...
Borges, Daniel Filipe; Soares, Joana I.; Casalta-Lopes, João; Ferreira, Marta Pereira; Carvalho, RubenHigh-grade gliomas are the most common type of malignant glioma. Seizures are frequently the first clinical manifestation of high-grade gliomas. Seizure-control is one of the main goals of treatment due to the impact in quality of life of these patients. Besides it impacts in morbidity and mortality rates there is a lack of evidence in the prevalence of post- therapy epilepsy. Our main goal was to evaluate the ...
Small cell neuroendocrine carcinoma of the larynx: a clinical case and literatu...
Alves, Alice; Fernandes, Catarina; Machado-Neves, Raquel; Ferreira Penêda, José; Vilaça, Marta; van Elzen, Catarina; Martins, Filipa; Lopes, GustavoNeuroendocrine carcinomas (NEC) are rare and heterogeneous tumours in the Head and Neck (HN), especially in the larynx, representing less than 1% of primary tumours. They are classified into different grades according to cellular differentiation. Treatment is multidisciplinary and includes chemotherapy, surgery, and radiotherapy. We describe the case of a 73-year-old patient with progressive dysphonia and laryn...
Platinum(II) ring-fused chlorins as efficient theranostic agents: Dyes for tumo...
Laranjo, Mafalda; Aguiar, Márcia Campos; Pereira, Nelson A. M.; Brites, Gonçalo; Nascimento, Bruno F. O.; Brito, Ana F.; Casalta-Lopes, JoãoThe discovery of Pt-chlorin-type theranostic agents is described. Luminescent Pt(II) 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused chlorins, with different degrees of hydrophilicity, have been synthesized and their in vitro photocytotoxicity against human melanoma, oesophageal and bladder carcinomas was studied. A di(hydroxymethyl)-substituted chlorin was identified as a privileged molecule to explore imaging...
Evaluation of dentinogenesis inducer biomaterials: an in vivo study
Paula, Anabela B.; Laranjo, Mafalda; Marto, Carlos Miguel; Paulo, Siri Folques Vicente de; Abrantes, Ana M.; Fernandes, Bruno; Casalta-Lopes, JoãoWhen exposure of the pulp to external environment occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain pulp tissue vitality and function. These clinical situations require the use of materials that induce dentin repair and, subsequently, formation of a mineralized tissue. Objective: This work aims to assess the effect of tricalcium silicate cements and mineral trioxide aggregate c...
Cytotoxic Effects of Zoom® Whitening Product in Human Fibroblasts
Marto, Carlos Miguel; Laranjo, Mafalda; Paula, Anabela; Coelho, Ana Sofia; Abrantes, Ana Margarida; Casalta-Lopes, João; Gonçalves, Ana CristinaTooth whitening procedures are increasing; however, side effects can occur, such as damage to pulp cells, by the whitening products. This study aims to assess the cellular effects promoted by a whitening product, namely, the oxidative stress fostered by the active agent hydrogen peroxide, with and without photoactivation. Additionally, if cellular recovery occurred, we intended to determine the time point where...
Calcium Phosphate Ceramics Can Prevent Bisphosphonate-Related Osteonecrosis of ...
Paulo, Siri; Laranjo, Mafalda; Paula, Anabela; Abrantes, Ana Margarida; Martins, João; Marto, Carlos Miguel; Coelho, Ana Sofia; Casalta-Lopes, JoãoBisphosphonate-associated osteonecrosis of the jaw (BRONJ), a post-surgical non-healing wound condition, is one of the most common side effects in patients treated with nitrogen-containing bisphosphonates. Its physiopathology has been related with suppression of bone turnover, of soft tissue healing and infection. Biphasic calcium phosphates (BCP) are used as a drug delivery vehicle and as a bone substitute in ...
GuttaFlow® Bioseal Cytotoxicity Assessment: In Vitro Study
Ferreira, Inês; Laranjo, Mafalda; Marto, Carlos Miguel; Casalta-Lopes, João; Serambeque, Beatriz; Gonçalves, Ana Cristina; Sarmento-Ribeiro, Ana BelaThe sealers used for root canal treatment should be biocompatible for the peri-radicular tissues, to evaluate the cytotoxic effects of GuttaFlow® bioseal sealer and to compare them with AH26® epoxy resin. Culture media were conditioned with the GuttaFlow® bioseal and AH26® pellets. MDPC-23 odontoblast cell cultures were treated with conditioned medium and serial dilutions. To evaluate the metabolic activity and...
EPISCLERAL BRACHYTHERAPY IN PORTUGAL:
Fonseca, Cristina; Albuquerque, Maria; Rodrigues, Tiago M; Casalta-Lopes, João; Teixeira, Tânia; Simões, Paulo César; Cachulo, Maria da LuzOBJECTIVOS: Avaliar o desempenho do Centro de Referência Português de Onco-Oftalmologia no que diz respeito ao controlo local, taxas de sobrevida, taxas de metastização e efeitos secundários da Braquiterapia Episcleral (BTE), e comparar estes resultados com a literatura. MATERIAL E MÉTODOS: Estudo prospectivo e consecutivo que incluiu os doentes referenciados ao Centro de Referência de Onco-Oftamologia por mela...
Biodentine™ Boosts, WhiteProRoot®MTA Increases and Life® Suppresses Odontoblast...
Paula, Anabela; Laranjo, Mafalda; Marto, Carlos Miguel; Abrantes, Ana Margarida; Casalta-Lopes, João; Gonçalves, Ana Cristina(1) Background: When pulp exposure occurs, reparative dentinogenesis can be induced by direct pulp capping to maintain the vitality and function of the tissue. The aim of this work was to assess the cytotoxicity and bioactivity of three different direct pulp capping materials, calcium hydroxide (Life®), mineral trioxide aggregate (WhiteProRoot®MTA) and calcium silicate (Biodentine™), in an odontoblast-like mous...
Direct Pulp Capping: Which is the Most Effective Biomaterial? A Retrospective C...
Paula, Anabela; Carrilho, Eunice; Laranjo, Mafalda; Abrantes, Ana M.; Casalta-Lopes, João; Botelho, Maria Filomena; Marto, Carlos Miguel(1) Background: Recently, tricalcium silicate cements, such as Biodentine™, have emerged. This biomaterial has a calcium hydroxide base and characteristics like mineral aggregate trioxide cements, but has tightening times that are substantially more suitable for their application and other clinical advantages. (2) Methods: A retrospective clinical study was conducted with 20 patients, which included a clinical ...