6 documents found, page 1 of 1
Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neu...
Bastard, Paul; Vazquez, Sara E.; Liu, Jamin; Laurie, Matthew T.; Wang, Chung Yu; Gervais, Adrian; Le Voyer, Tom; Bizien, Lucy; Zamecnik, ColinLife-threatening "breakthrough" cases of critical COVID-19 are attributed to poor or waning antibody (Ab) response to SARS-CoV-2 vaccines in individuals already at risk. Preexisting auto-Abs neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; their contribution to hypoxemic breakthrough cases in vaccinated people is unknown. We studied a cohort of 48 ...
Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected indivi...
Casanova, Jean-Laurent
Paracoccidioidomycosis Associated With a Heterozygous STAT4 Mutation and Impair...
Schimke, Lena F.; Hibbard, James; Martinez-Barricarte, Ruben; Khan, Taj Ali; Cavalcante, Ricardo de Souza [UNESP]; Oliveira Junior, Edgar Borges deMade available in DSpace on 2018-11-26T17:44:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-12-15; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Background. Mutations in genes affecting interferon-gamma (IFN-gamma) immunity have contributed to understand the role of IFN-gamma in protection against intracellular pat...
A three-dimensional model of human lung development and disease from pluripoten...
Chen, Ya-Wen; Huang, Sarah Xuelian; de Carvalho, Ana Luisa Rodrigues Toste; Ho, Siu-Hong; Islam, Mohammad Naimul; Volpi, Stefano; Notarangelo, Luigi D.Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three dimensions (3D) would allow deeper insight into human development, as well as the development of innovative strategies for disease modelling, drug discovery and regenerative medicine. We report here the generation from hPSCs of lung bud organoids (LBOs) that contain mesoderm and pulmonary endoderm and develop into branching ai...
Phagocyte nicotinamide adenine dinucleotide phosphate oxidase activity in patie...
Casanova, Jean-Laurent
Germline CYBB mutations that selectively affect macrophages in kindreds with X-...
Casanova, Jean-Laurent