17 documents found, page 1 of 2
The effect of conditioned medium from human amniotic membrane-derived mesenchym...
Silva, C. S.; Casanova, Marta Alexandra Rodrigues; Ferreirinha, P.; da Silva Morais, A.; Osório, H.; Lima, A. C.; Fangueiro, J. F.; Cerqueira, M. T.Aims: The development and selection of T cells occur within the thymus. This organ involutes throughout life, compromising the generation of T cells and, consequently, the efficacy of the immune system. Mesenchymal stem cells (MSC) have beneficial effects on the immune system. Therefore, MSC have been applied in different pathologies related with thymic function. However, there is a lack of knowledge on the pot...
Microfluidic-derived docosahexaenoic acid liposomes for targeting glioblastoma ...
Mendanha, Daniel; Casanova, Marta Alexandra Rodrigues; Gimondi, Sara; Ferreira, Helena Susana Costa Machado; Neves, N. M.Glioblastoma (GBM) is the most common malignant primary brain tumor, characterized by limited treatment options and a poor prognosis. Its aggressiveness is attributed not only to the uncontrolled proliferation and invasion of tumor cells but also to the complex interplay between these cells and the surrounding microenvironment. Within the tumor microenvironment, an intricate network of immune cells, stromal cel...
Advancing diagnostics and disease modeling: current concepts in biofabrication ...
Casanova, César R.; Casanova, Marta Alexandra Rodrigues; Reis, R. L.; Oliveira, Joaquim M.Soft microfluidic systems play a pivotal role in personalized medicine, particularly in in vitro diagnostics tools and disease modeling. These systems offer unprecedented precision and versatility, enabling the creation of intricate three-dimensional (3D) tissue models that can closely emulate both physiological and pathophysiological conditions. By leveraging innova- tive biomaterials and bioinks, soft microfl...
The biomimetic surface topography of Rubus fruticosus leaves stimulate the indu...
Monteiro, N. O.; Casanova, Marta Alexandra Rodrigues; Fangueiro, J. F.; Reis, R. L.; Neves, N. M.The interaction between cells and biomaterials is essential for the success of biomedical applications in which the implantation of biomaterials in the human body is necessary. It has been demonstrated that material's chemical, mechanical, and structural properties can influence cell behaviour. The surface topography of biomaterials is a physical property that can have a major role in mediating cellâ material i...
Macrophage cell membrane infused biomimetic liposomes for glioblastoma targeted...
Mendanha, D.; Vieira de Castro, J.; Casanova, Marta Alexandra Rodrigues; Gimondi, Sara; Ferreira, H.; Neves, N. M.Glioblastoma (GBM) is a highly aggressive malignant brain tumor currently without an effective treatment. Inspired by the recent advances in cell membrane biomimetic nanocarriers and by the key role of macrophages in GBM pathology, we developed macrophage membrane liposomes (MML) for GBM targeting. For the first time, it was assessed the role of macrophage polarization states in the effectiveness of these drug ...
Biomimetic surface topography as a potential modulator of macrophages inflammat...
Monteiro, N. O.; Casanova, Marta Alexandra Rodrigues; Quinteira, R.; Fangueiro, J. F.; Reis, R. L.; Neves, N. M.The implantation of biomaterial devices can negatively impact the local microenvironment through several processes including the injury incurred during the implantation process and the associated host inflammatory response. Immune cell responses to implantable biomaterial devices mediate host-material interactions. Indeed, the immune system plays a central role in several biological processes required for the i...
Stimulation of neurite outgrowth using autologous NGF bound at the surface of a...
Casanova, Marta Alexandra Rodrigues; Reis, R. L.; Martins, Albino; Neves, N. M.Peripheral nerve injury still remains a major clinical challenge, since the available solutions lead to dysfunctional nerve regeneration. Even though autologous nerve grafts are the gold standard, tissue engineered nerve guidance grafts are valid alternatives. Nerve growth factor (NGF) is the most potent neurotrophic factor. The development of a nerve guidance graft able to locally potentiate the interaction be...
Chondrogenic differentiation induced by extracellular vesicles bound to a nanof...
Casanova, Marta Alexandra Rodrigues; Osório, Hugo; Reis, R. L.; Martins, Albino; Neves, N. M.Extracellular vesicles (EVs) are being increasingly studied owing to its regenerative potential, namely EVs derived from human bone marrow mesenchymal stem cells (hBM-MSCs). Those can be used for controlling inflammation, repairing injury, and enhancing tissue regeneration. Differently, the potential of EVs derived from human articular chondrocytes (hACs) to promote cartilage regeneration has not been thoroughl...
Surface biofunctionalization to improve the efficacy of biomaterial substrates ...
Casanova, Marta Alexandra Rodrigues; Reis, R. L.; Martins, Albino; Neves, N. M.Surface biofunctionalization has emerged in the past decade as a rising tool in Tissue Engineering and Regenerative Medicine (TERM) approaches. The development of biomaterial substrates with regenerative properties is challenging, mainly due to the requirement of obtaining a surface that promotes cell attachment, proliferation and differentiation. Biomolecules, namely extracellular matrix proteins and growth fa...
Surface biofunctionalization of polycaprolactone fibrous meshes for skeletal an...
Casanova, Marta Alexandra RodriguesDamage of the skeletal and neural tissues has a significant impact over the quality-of-life of patients and high socio-economical costs. Current treatment options are not effective in long term, due to the suboptimal integration with the host tissue and limited bioactivity of implantable biomaterials. The immobilization of biomolecules at the surface of biomedical devices has attracted increasing interest, allo...