6 documents found, page 1 of 1
Action of Curcumin on Glioblastoma Growth: A Systematic Review with Meta-Analys...
Luís, Ângelo; Amaral, Leonor; Domingues, F.C.; Pereira, L.; Cascalheira, JoséGliomas are aggressive brain tumors with poor prognosis even after surgical removal and radio-chemotherapy, stressing the urgency to find alternative therapies. Several preclinical studies evaluating the anticancer effect of curcumin in animal models of glioma are reported, but a systematic review with meta-analysis of these studies, considering the different experimental conditions used, has not been made up t...
The role of ayahuasca in cell viability and oxidative stress in gastric adenoca...
Gonçalves, Joana; Cascalheira, José; Valentão, Patrícia; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaAyahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,Ndimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This...
Therapeutic Potential of Resveratrol for Glioma: A Systematic Review and Meta-A...
Luís, Ângelo; Marcelino, Helena; Domingues, F.C.; Pereira, L.; Cascalheira, JoséGliomas are aggressive malignant brain tumors, with poor prognosis despite available therapies, raising the necessity for finding new compounds with therapeutic action. Numerous preclinical investigations evaluating resveratrol’s anti-tumor impact in animal models of glioma have been reported; however, the variety of experimental circumstances and results have prevented conclusive findings about resveratrol’s e...
The sex bias of cancer
Costa, Ana Raquel; Cruz, Inês; Oliveira, Mariana Lança de; Gonçalves, Isabel; Cascalheira, José; Santos, CeciliaIn cancers of hormone-dependent organs like women breast and reproductive organs, endometrium and ovaries, and men’s prostate and testicular cancer, the roles of sex hormones and deregulation of hormone axes are well-documented. More strikingly, epidemiological data highlights significant differences between sexes in the incidence of various cancers in non-reproductive organs, where the role of sex hormones has...
The effects of cannabinoids on glioblastoma growth: A systematic review with me...
Luís, Ângelo; Marcelino, Helena; Rosa, Carolina Boialvo; Domingues, F.C.; Pereira, L.; Cascalheira, JoséGlioblastoma multiforme (GBM) is the most frequent and aggressive malignant brain tumour, with a poor prognosis despite available surgical and radio-chemotherapy, rising the necessity for searching alternative therapies. Several preclinical studies evaluating the efficacy of cannabinoids in animal models of GBM have been described, but the diversity of experimental conditions and of outcomes hindered definitive...
Adenosine inhibits human astrocyte proliferation independently of adenosine rec...
Marcelino, Helena; Nogueira, Vanda Cristina Simões; Santos, Cecilia; Quelhas, Patricia; Carvalho, Tiago; Gomes, João Fonseca; Tomás, JoanaBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor-independent mechanism by reversing the reaction catalysed by S-adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S-adenosylmethionine (SAM)-dependent methyltransferases. Astrocyte...