8 documents found, page 1 of 1
Unlocking the role of metabolic pathways in brain metastatic disease
Pinto, Madalena; Violante, Sara; Cascao, Rita; Faria, ClaudiaThe dissemination of malignant cells to the brain is a late-stage complication of cancer, leading to significant morbidity and mortality. Brain metastases (BM) affect 20-30% of cancer patients, primarily originating from lung cancer, breast cancer, and melanoma. Despite advances in molecular-targeted therapies, brain metastatic disease remains incurable, with a poor median survival of ≤12 months if left untreat...
Immunotherapy in lung cancer brain metastases
Paisana, Eunice; Cascao, Rita; Alvoeiro, Magda; Félix, Francisco; Martins, Guilherme; Guerreiro, Carla; Roque, Rafael; Cruz, Rafael Moiteiro DaBrain metastases (BM) occur frequently in lung cancer, particularly in non-small cell lung cancer (NSCLC) patients and remain a significant cause of morbidity and mortality. Standard therapies have limited efficacy due to poor crossing of the blood-brain barrier and the distinct features between BM and the primary tumor. This review explores the immune landscape of brain metastatic disease, emerging immunothera...
Role of UBE2C in brain cancer invasion and dissemination
Domentean, Stefani; Paisana, Eunice; Cascao, Rita; Faria, ClaudiaGlioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary or metastatic brain cancer cells, whose triggering mechanisms are largely unknown. Emerging evidence has suggested that the ubiquitin-conjugating enzyme E2C (UBE2C)...
Celastrol efficacy by oral administration in the adjuvant-induced arthritis model
Cascao, Rita; Vidal, Bruno; Carvalho, Tânia; Lopes, Inês; Romão, Vasco C.; Goncalves, Joao; Moita, Luis; Fonseca, João EuricoBackground: We previously demonstrated that celastrol has significant anti-inflammatory and bone protective effects when administered via the intraperitoneal route. For further preclinical evaluation, an effective oral administration of celastrol is crucial. Here we aimed to study the therapeutic dose range for its oral administration. Methods: Celastrol (1-25 μg/g/day, N = 5/group) was administrated orally to ...
Effect of celastrol on bone structure and mechanics in arthritic rats
Cascao, Rita; Vidal, Bruno; Jalmari Finnilä, Mikko Arttu; Lopes, Inês; Teixeira, Rui Lourenço; Saarakkala, Simo; Moita, Luis FerreiraObjective: Rheumatoid arthritis (RA) is characterised by chronic inflammation leading to articular bone and cartilage damage. Despite recent progress in RA management, adverse effects, lack of efficacy and economic barriers to treatment access still limit therapeutic success. Therefore, safer and less expensive treatments that control inflammation and bone resorption are needed. We have previously shown that ce...
Decrease of CD68 synovial macrophages in celastrol treated arthritic rats
Cascao, Rita; Vidal, Bruno; Lopes, Inês; Paisana, Eunice; Rino, José; Moita, Luis; Fonseca, João EuricoBackground: Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost. Therefore, compounds that can control arthritis, with an acce...
Arthritis induces early bone high turnover, structural degradation and mechanic...
Vidal, Bruno; Cascao, Rita; Vale, Ana Catarina; Cavaleiro, Inês; Vaz, Maria Fátima; Brito, José Américo Almeida; Canhao, Helena; Fonseca, João EuricoBackground: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and degradation of bone biomechanical properties. The main goal of the present work was to study the effects of the first days of the inflammatory process on the micr...
Role of IL-1β in rheumatoid arthritis
Cascao, RitaRheumatoid arthritis is a chronic inflammatory and immuno-mediated disease with a significant involvement of the synovial membrane of multiple small joints and progressive destruction of cartilage and bone, which leads to functional impairment and a significant increase of both morbidity and mortality of patients. Early diagnosis and an accurate prompt therapeutic strategy are crucial to prevent rheumatoid arth...