16 documents found, page 1 of 2
Fluorescent Marinoquinoline Derivative as Inhibitors of Plasmodium falciparum
Santos Barbosa, Patricia; Souza, Guilherme Eduardo; Maluf, Sarah El Chamy; Bonatto, Vinícius; Moura, Caio Silva; Mendes, Giovana RossiWe present insights into the mechanism of action of marinoquinolines (MQ), a novel class of lead candidates. Using a divergent synthetic approach, we developed a series of 20 new analogues with fluorescence properties. Structure–activity relationships analysis identified 19 as an attractive compound showing a combination of favorable in vitro (IC503D7= 0.28 μM; CC50HepG2= 53 μM), ex vivo (EC50Pf= 1.2 μM; EC50Pv...
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and la...
Ferreira, Letícia Tiburcio; Cassiano, Gustavo Capatti; Alvarez, Luis Carlos Salazar; Okombo, John; Calit, Juliana; Fontinha, Diana; Gil-Iturbe, EvaArtemisinin-based combination therapy (ACT) is the mainstay of effective treatment of Plasmodium falciparum malaria. However, the long-term utility of ACTs is imperiled by widespread partial artemisinin resistance in Southeast Asia and its recent emergence in parts of East Africa. This underscores the need to identify chemotypes with new modes of action (MoAs) to circumvent resistance to ACTs. In this study, we...
Antimalarial and cytotoxic activity of native plants used in cabo verde traditi...
Essoh, Anyse P.; Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, Monica B.M.V.Medicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Siderox...
Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditi...
Essoh, Anyse P.; Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, MónicaMedicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Siderox...
Antimalarial and cytotoxic activity of native plants used in Cabo Verde traditi...
Essoh, Anyse P.; Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, MónicaMedicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Siderox...
Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditi...
Essoh, Anyse P.; Cassiano, Gustavo Capatti; Mandim, Filipa; Barros, Lillian; Gomes, Isildo; Medeiros, Márcia Melo; Moura, MónicaMedicinal plants have historically been a source of drugs in multiple applications, including the treatment of malaria infections. The Cabo Verde archipelago harbors a rich diversity of native plants, most of which are used for medicinal purposes. The present study investigated the in vitro antiplasmodial activities of four native plants from Cabo Verde (i.e., Artemisia gorgonum, Lavandula rotundifolia, Siderox...
Polymorphism in the IL-1? promoter is associated with IgG antibody response to ...
Capobianco, Marcela Petrolini; Cassiano, Gustavo Capatti; Storti-Melo, Luciane Moreno; Pimenta, Tamirys Sim?o; Rodrigues, Ana Paula DrummondConselho Nacional para o Desenvolvimento Cient?fico e Tecnol?gico (CNPq) ; Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Brazil (CAPES ? DS and PDSE) ? Finance Code 001; S?o Paulo State University. Graduate Program in Biosciences. S?o Jos? do Rio Preto, SP, Brazil.; Lisboa University. Tropical Medicine and Hygiene Institut. Global Health and Tropical Medicine. Lisboa, Portugal.; Federal Universit...
Frequency of TNFA, INFG, and IL10 Gene Polymorphisms and Their Association with...
Cruz Furini, Adriana Antonia da; Cassiano, Gustavo Capatti; Capobianco, Marcela Petrolini [UNESP]; Batista dos Santos, Sidney EmanuelMade available in DSpace on 2018-11-26T17:13:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Polymorphisms in cytokine genes can alter the production of these proteins and consequently affect the immune response. The trihybrid heterogeneity of the Brazilian ...
Polymorphisms in Plasmodium vivax circumsporozoite protein (CSP) influence para...
Ribeiro, Bruno de Paulo; Cassiano, Gustavo Capatti; Souza, Rodrigo Medeiros de; Cysne, Dalila Nunes; Grisotto, Marcos Augusto GrigolinUniversidade Federal do Maranh?o. Programa de P?s- gradua??o em Ci?ncias da Sa?de. S?o Lu?s, MA, Brazil / Universidade Federal do Maranh?o. Laborat?rio de Imunofisiologia. S?o Lu?s, MA, Brazil.; Faculdade de Medicina de S?o Jos? do Rio Preto. Centro de Investiga??o de Microrganismos. S?o Jos? do Rio Preto, SP, Brazil.; Universidade de S?o Paulo. Instituto de Ci?ncias Biol?gicas. Departamento de Parasitologia. S...
Immunogenetic markers associated with a naturally acquired humoral immune respo...
Cassiano, Gustavo Capatti; Furini, Adriana A. C; Capobianco, Marcela P; Storti-Melo, Luciane M; Almeida, Maria E; Barbosa, Danielle Regina LimaS?o Paulo State University. Department of Biology. S?o Jos? do Rio Preto, SP, Brazil / S?o Jos? do Rio Preto Medical School. Department of Skin. Infectious and Parasitic Diseases. S?o Jos? do Rio Preto, SP, Brazil.; S?o Jos? do Rio Preto Medical School. Department of Skin. Infectious and Parasitic Diseases. S?o Jos? do Rio Preto, SP, Brazil.; S?o Jos? do Rio Preto Medical School. Department of Skin. Infectious ...