5 documents found, page 1 of 1
A multicentric analysis of prognostic factors in malignant pleural mesothelioma
Batista, Mafalda; Barata, Juliana; Costa-Martins, Sara; Valente, Maria Jesus; Oliveira Fernandes, Maria Gabriela; Saleiro, Sandra; Souto Moura, MadalenaBackground: Malignant pleural mesothelioma is a rare entity with poor prognosis, linked to previous asbestos exposure. The main goal of this study was to analyse the impact of clinical factors on mesothelioma prognosis. Methods: Retrospective cohort study of patients with malignant pleural mesothelioma in three Portuguese institutions, from 1999 to 2020. Statistical analysis was performed with Kaplan–Meier meth...
Persistent fever and hemoptoic sputum – clinical case
Mosca, Sara; Magalhães, Adriana; Couto Guerra, Isabel; Azevedo, InêsForeign body aspiration (FBA) is a common and serious problem in children. Considering that signs and symptoms can be non-specific and subtle, it is of utmost importance to recognize vulnerable patient groups, combine an accurate history with complete physical examination, and follow a structured diagnostic approach towards correct diagnosis. In the present case, a high index of suspicion was essential to preve...
Persistent fever and hemoptoic sputum – clinical case
Mosca, Sara; Magalhães, Adriana; Couto Guerra, Isabel; Azevedo, InêsForeign body aspiration (FBA) is a common and serious problem in children. Considering that signs and symptoms can be non-specific and subtle, it is of utmost importance to recognize vulnerable patient groups, combine an accurate history with complete physical examination, and follow a structured diagnostic approach towards correct diagnosis. In the present case, a high index of suspicion was essential to preve...
Resistance profile of osimertinib in pre-treated patients with EGFR T790M-mutat...
Fernandes, Maria Gabriela O.; Sousa, Catarina; Jacob, Maria; Almeida, Leonor; Santos, Vanessa; Araújo, David; Bastos, Hélder Novais; Magalhães, AdrianaOsimertinib efficacy in pre-treated patients with epidermal growth factor receptor (EGFR) T790M-mutated non-small cell lung cancer (NSCLC) has been demonstrated in clinical trials, but real-world data, particularly regarding resistance profile, remains limited. This study aims to analyze the resistance mechanisms acquired after treatment with Osimertinib. Clinical outcomes and molecular results from re-biopsie...
Influence of emphysema distribution on pulmonary function parameters in COPD pa...
Bastos, Hélder Novais; Neves, Inês; Redondo, Margarida; Cunha, Rui; Pereira, José Miguel; Magalhães, Adriana; Fernandes, GabrielaObjective: To evaluate the impact that the distribution of emphysema has on clinical and functional severity in patients with COPD. Methods: The distribution of the emphysema was analyzed in COPD patients, who were classified according to a 5-point visual classification system of lung CT findings. We assessed the influence of emphysema distribution type on the clinical and functional presentation of COPD. We al...