248 documents found, page 1 of 25
Self-assembly pathway influence on Dehydropeptide-based gel properties and drug...
Veloso, Sérgio R S; Vijayakanth, Thangavel; Shankar, Sudha; Fridman, Natalia; Rencus-Lazar, Sigal; Hilliou, L.; Rodrigues, Pedro V.; Moura, C.Low-molecular-weight peptide-based hydrogels formed through self-assembly have emerged as promising candidates for biomedical applications. While the self-assembly process is known to affect the network morphology, its impact on mechanical properties and drug delivery remains poorly understood. In this work, it is explored how different gelation conditions influence the morphology, properties, and drug release ...
Multifunctional magneto-plasmonic lipogel based on peptide hydrogel for applica...
Gomes, Valéria; Veloso, Sérgio R. S.; Carvalho, André; Hilliou, L.; Coutinho, Paulo J. G.; Moura, C.; Martins, J. A. R.; Castanheira, Elisabete M. S.Supramolecular hydrogels, particularly low-molecular-weight peptide hydrogels, are promising drug delivery systems due to their ability to change the solubility, targeting, metabolism and toxicity of drugs. Magneto-plasmonic liposomes, in addition to being remotely controllable with the application of an external magnetic field, also increase the efficiency of encapsulated drug release through thermal stimulati...
Albumin/Hyaluronic acid nanoparticle-laden contact lenses for the ocular delive...
Senra, Sara F. M.; Veloso, Sérgio Rafael Silva; Lira, Madalena; Castanheira, Elisabete M. S.Nanoparticle-laden contact lenses are a formidable strategy for ocular drug delivery. However, incorporating nanoparticles to achieve sustained drug release without affecting the contact lenses' properties remains a challenging task. In this work, daily and monthly replacement silicone-hydrogel contact lenses laden with bovine serum albumin/hyaluronic acid (BSA/HA) nanoparticles are presented. These nanoparticl...
Evaluation of the photothermal performance of the Prussian blue/hydroxyapatite ...
Costa, Achilley Nahid Barros; Serra, Josilene Lima; da Luz Rodrigues, Israel; Mendonça, Leonardo Tadeu Boaes; Pereira, GoretiIn this study, Prussian Blue (PB) and hydroxyapatite (HAp) composites were developed and synthesized in situ within an alginate gel, resulting in materials with excellent photothermal conversion efficiency. Structural information and morphology of the composites were obtained by using X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), UV–vis absorption spectroscopy, and Scanning Electron M...
Magnetic lipid-based nanoparticles: recent advances in therapeutic applications
Andrade, Raquel G. D.; Veloso, Sérgio Rafael Silva; Castanheira, Elisabete M. S.; Rodrigues, L. R.In the realm of modern medicine, the pursuit of innovative solutions to enhance therapeutic applications has led to the exploration of cutting-edge technologies. The convergence of nanotechnology and medicine has marked a new era, where the scale of interventions has shifted to the molecular level. Nanoparticles with their ability to navigate through biological barriers, coupled with the potential for targeted ...
2,4,5-Triaminopyrimidines as blue fluorescent probes for cell viability monitor...
Gonçalves, Jorge M.; Gonçalves, João N. D.; Sousa, Luís F.; Rodrigues, L. R.; Correia-de-Sá, Paulo; Coutinho, Paulo J. G.; Castanheira, Elisabete M. S.Monitoring cell viability is critical in cell biology, pathology, and drug discovery. Most cell viability assays are cell-destructive, time-consuming, expensive, and/or hazardous. Herein, we present a series of newly synthesized 2,4,5-triaminopyrimidine derivatives able to discriminate between live and dead cells. To our knowledge, these compounds are the first fluorescent nucleobase analogues (FNAs) with cell ...
Elastic liposomes containing calcium/magnesium ferrite nanoparticles coupled wi...
Pacheco, Ana Rita Faria; Barros, Ana Margarida; Amorim, Carlos O.; Amaral, Vítor S.; Coutinho, Paulo J. G.; Rodrigues, Ana Rita OliveiraThis work reports on the design, development, and characterization of novel magneto-plasmonic elastic liposomes (MPELs) of DPPC:SP80 (85:15) containing Mg0.75Ca0.25Fe2O4 nanoparticles coupled with gold nanorods, for topical application of photothermal therapy (PTT). Both magnetic and plasmonic components were characterized regarding their structural, morphological, magnetic and photothermal properties. The magn...
An injectable composite co‐assembled dehydropeptide‐based magnetic/plasmonic li...
Veloso, Sérgio R. S.; Vázquez‐González, Margarita; Spuch, Carlos; Freiría‐Martínez, Luis; Comís‐Tuche, María; Iglesias‐Martínez‐Almeida, MartaAdvancing therapeutic effectiveness through the strategic co-delivery of drugs in a sequential manner represents a compelling strategy. However, achieving precise and selective release of chemotherapeutic agents remains a formidable challenge. In this study, a co-assembled Arginine-Glycine-Aspartate (RGD)-functionalized dehydropeptide-based gel loaded with magnetic liposomes and mesoporous silica-coated gold na...
Nanoformulações de um novo composto muito promissor para terapia do cancro da m...
Teixeira, Marta Sofia Vilela Barreira; Ferreira, Débora Carina Gonçalves Abreu; Rodrigues, L. R.; Castanheira, Elisabete M. S.; Carvalho, M. AliceNo presente estudo pretendeu-se desenvolver, caracterizar e avaliar o efeito antitumoral de nanoformulações carregadas com o composto Hit. As formulações carregadas com o composto hit foram caracterizadas por DLS (tamanho hidrodinâmico, índice de polidispersividade e potencial zeta), e a cinética de libertação do composto. Adicionalmente, os efeitos antitumorais das nanoformulações foram determinados na linha c...
New strategies for multimodal cancer therapy based on plasmonic lipogels
Veloso, Sérgio Rafael Silva; Sá, Filipa Costa e; Comís-Tuche, María; Spuch, Carlos; Castanheira, Elisabete M. S.Enhancing the therapeutic efficacy of chemotherapeutic agents through sequential drug delivery holds immense promise, yet current strategies are mainly dependent on the tumour microenvironment. Natural polymer-based hydrogels present suitable properties for these applications, owing to their inherent biocompatibility [1]. Herein, we present a novel strategy aimed at improving the tunability and real-time contro...