4 documents found, page 1 of 1
What is the impact of thiamine deficiency on cognitive function in patients wit...
Teixeira, Joana; Pereira, Inês; Castanho, Miguel; Couto, Frederico Simões doCognitive impairments are frequently observed in patients with Alcohol Use Disorder (AUD). Thiamine deficiency is often found in AUD patients and has been suggested as a possible cause of cognitive impairments. While thiamine deficiency is not consistently present in all AUD patients with cognitive deficits, thiamine is traditionally prescribed to patients with AUD to treat or prevent cognitive impairment. To b...
Highly specific blood-brain barrier transmigrating single-domain antibodies sel...
Aguiar, Sandra Isabel; Dias, Joana N. R.; S. André, Ana; Silva, Lisete M.; Martins, Diana; Carrapiço, Belmira; Castanho, Miguel; Carriço, JoãoA major bottleneck in the successful development of central nervous system (CNS) drugs is the discovery and design of molecules that can cross the blood-brain barrier (BBB). Nano-delivery strategies are a promising approach that take advantage of natural portals of entry into the brain such as monoclonal antibodies (mAbs) targeting endogenous BBB receptors. However, the main selected mAbs rely on targeting broa...
Fast NMR method to probe solvent accessibility and disordered regions in proteins
Faustino, André F.; Barbosa, Glauce M.; Silva, Micael; Castanho, Miguel; Da Poian, Andrea T .; Cabrita, Eurico J.; Santos, Nuno C.; Almeida, Fabio C. L.Understanding protein structure and dynamics, which govern key cellular processes, is crucial for basic and applied research. Intrinsically disordered protein (IDP) regions display multifunctionality via alternative transient conformations, being key players in disease mechanisms. IDP regions are abundant, namely in small viruses, allowing a large number of functions out of a small proteome. The relation betwee...
FEBS 50th Anniversary Virtual Issue: Portugal
Aureliano, M.; Antunes, Fernando; Castanho, Miguel; Marcos, João Carlos; Soveral, GraçaThis celebratory Virtual Issue for the 50th anniversary of FEBS (2014) highlights the high quality and diversity of biochemistry research carried out in Portugal. Up to 2013, 303 articles were published in FEBS Letters and The FEBS Journal / European Journal of Biochemistry with at least one author having Portugal as an address.