8 documents found, page 1 of 1
Direct tissue-sensing reprograms TLR4+ Tfh-like cells inflammatory profile in t...
Amaral-Silva, Daniela; Gonçalves, Rute; Torrão, Rita C.; Torres, Rita; Falcão, Sandra; Gonçalves, Maria João; Araújo, Maria Paula; Martins, Maria JoséFunding Information: We thank Cláudia Andrade for technical support and Juliana Gonçalves for testing samples for SARS-CoV-2 exposure. We are extremely grateful to all the participants of the study and to the whole rheumatology department at Hospital Egas Moniz that made this study possible. This work was supported by Fundação para a Ciência e Tecnologia (FCT) PTDC/MEC-REU/29520/2017, by iNOVA4Health UID/Multi/...
Reuma.pt/vasculitis - the Portuguese vasculitis registry
Ponte, Cristina; Khmelinskii, Nikita; Teixeira, Vítor; Luz, Karine; Peixoto, Daniela; Rodrigues, Marília; Luís, Mariana; Teixeira, Lídia; Sousa, SandraBACKGROUND: The vasculitides are a group of rare diseases with different manifestations and outcomes. New therapeutic options have led to the need for long-term registries. The Rheumatic Diseases Portuguese Register, Reuma.pt, is a web-based electronic clinical record, created in 2008, which currently includes specific modules for 12 diseases and > 20,000 patients registered from 79 rheumatology centres. On Oct...
Predictors and causes of first-line biologic agent discontinuation in rheumatoi...
Gomes, JL; Sepriano, Alexandre; Eusébio, Mónica; Silvério Serra, Sofia; Fonseca, João Eurico; Saavedra, Maira João; Cunha-Miranda, Luís; Silva, CândidaOBJECTIVES: To assess the discontinuation of first-line biological treatment and to evaluate the reasons and predictors thereof in patients with rheumatoid arthritis (RA) from daily clinical practice. METHODS: RA patients registered in the Rheumatic Diseases Portuguese Register (Reuma.pt) starting treatment with biologic DMARDs (bDMARDs) were included in this prospective observational study. The main outcome wa...
Childhood hypophosphatasia with myopathy: clinical report with recent update
Silva, I; Castelão, Walter; Mateus, M; Branco, JaimeHypophosphatasia is a rare genetic disease with low tissue nonspeficic alkaline phosphatase activity (TNSALP), due to ALPL gene mutation. There are 6 clinical forms. Childhood form is caractherized by short stature, premature loss of decidous teeth and diffuse bone pain associated with a pathological bone fracture in the past. Laboratory findings present low serum level of alkaline phosphatase and high levels o...
Envolvimento muscular na esclerose sistémica - Avaliação diagnóstica
Pinto, Laura; Castelão, Walter; Branco, JaimeIn Systemic Sclerosis skeletal muscle may be involved. Several published series describe different involvement percentages, depending on the diagnostic criteria used. To date, there are no uniform criteria for the diagnosis of this entity and, the use of new methods, namely imunohistoquimic techniques, will be necessary to highlight the different types of muscle involvement ocurring in this disease. The present...
Envolvimento muscular na esclerose sistémica - avaliação diagnóstica
Pinto, Laura; Castelão, Walter; Branco, JaimeIn Systemic Sclerosis skeletal muscle may be involved. Several published series describe different involvement percentages, depending on the diagnostic criteria used. To date, there are no uniform criteria for the diagnosis of this entity and, the use of new methods, namely imunohistoquimic techniques, will be necessary to highlight the different types of muscle involvement ocurring in this disease. The present...
Recomendações portuguesas para utilização de metotrexato no tratamento de doenç...
Canhão, Helena; Santos, Maria José; Costa, Maria Lúcia; Bogas, Mónica; Mourão, Ana Filipa; Machado, Pedro; Fonseca, João EuricoObjectives:To develop Portuguese evidence-based recommendations for the use of methotrexate (MTX) in daily clinical practice in rheumatic disorders. Methods:The Portuguese project was integrated in the multinational 3E Initiative (Evidence, Expertise, Exchange) 2007-2008 where a total of 751 rheumatologists from 17 countries have participated. Ten clinical questions concerning the use of MTX in rheumatic diseas...
Associação entre presença de factores reumatóides 16M no soro e resposta à tera...
Mourão, Ana Filipa; M. Pimentel-Santos, F.; Falcao, Sandra; Barros, Rita; Pinto, Teresa Laura; Mendes, Alexandra; Castelão, Walter; Nero, PatríciaAIM To verify if the response to TNFalpha inhibitors is influenced by the presence of IgM rheumatoid factor (RF), in patients with RA. MATERIAL AND METHODS In this study, the patients with the diagnosis of RA treated with TNFa inhibitors followed in our hospital were recruited. A protocol was applied including demographic, clinical and laboratory data, in order to calculate DAS 28. The presence/absence of IgM R...