13 documents found, page 1 of 2
Potential herb-drug interactions found in a community pharmacy patients
Batista, C.; Pinho, C.; Castel-Branco, M. M.; Caramona, M. M.; Figueiredo, I. V.Phytotherapy has always played a leading role in therapeutics. However, a strong knowledge of the risk-benefit relationship of herbal products by patients and health professionals is necessary. The goals of this study were to characterize the consumption pattern of medicinal plants in patients in a community pharmacy, identify potential herb-drug interactions, and establish a list of recommendations for health ...
Medication follow-up in type 2 diabetes patients at a primary health care center
Figueiredo, I. V.; Móteiro, C.; Castel-Branco, M. M.; Caramona, M. M.; Fernandez-Llimos, F.Objetivo: Evaluar el impacto de un programa de seguimiento farmacoterapéutico de pacientes con diabetes mellitus en un centro de salud, mediante la evaluación de los resultados clínicos y humanísticos. Método: Estudio de intervención sobre una cohorte de pacientes en seguimiento farmacoterapéutico entre octubre 2011 y julio 2012. El médico de familia seleccionó todos los pacientes atendidos en el centro con dia...
As bases farmacológicas dos cuidados farmacêuticos: o caso dos AINEs.
Castel-Branco, M. M.; Santos, A.T.; Carvalho, R. M.; Caramona, M. M.; Santiago, L. M.; Fernandez-Llimos, Fernando; Figueiredo, Isabel V.A polimedicação aumenta o risco de reações adversas, interações e uso incorreto dos medicamentos. Nos idosos é bastante prevalente, potenciando ainda mais os problemas relacionados com os medicamentos, uma vez que estes também resultam das alterações fisiológicas e multimorbilidades do envelhecimento. Sabendo que os anti-inflamatórios não esteroides (AINEs) são fármacos muito usados pelos idosos, foram objetivo...
Efeito da adesão à terapêutica no estado de saúde do idoso
Mosca, C.; Castel-Branco, M. M.; Caramona, M. M.; Figueiredo, I. V.The prevalence of chronic diseases increases with age, and the constant growth of the overall population makes adherence to therapy a major challenge. A solution to the problem of non-adherence to therapy prescribed by the physician population is the implementation, in community pharmacy, of stock monitoring and pharmacist intervention. We evaluated 54 elderly patients treated with at least 3 drugs with an auto...
Necessidades reais de implementação de novos serviços farmacêuticos centrados n...
Castel-Branco, M. M.; Caramona, M. M.; Fernandez-Llimos, F.; Figueiredo, I. V.While new more potent and complex pharmaceutical agents are becoming available, increasing demands on doctors and the health care system, the increase of drug related morbidity and mortality throughout the world and rising costs related with the incorrect use of medicines make it clear that the identification of a practitioner who is available to focus on the management of all of a patient’s medicines would be ...
Hepatic and renal toxicities of indomethacin acid, salt form and complexed form...
Ribeiro-Rama, Ana Cristina; Figueiredo, Isabel Vitória; Veiga, Francisco José; Castel-Branco, M. M.; Cabrita, António M. Silvério; Caramona, MargaridaIndomethacin (IM), a non-steroidal anti-inflammatory drug, has the capacity to induce hepatic and renal injuries when administrated systemically. The aim of this study is to assess the IM absorption from complexed forms when orally administered to rats, by means of a comparative evaluation of its capacity to induce hepatic and renal injury in different forms, namely IM acid, IM sodium salt or IM complexed with ...
Evaluation of gastric toxicity of indomethacin acid, salt form and complexed fo...
Rama, A. C.; Figueiredo, Isabel Vitoria; Veiga, F.; Castel-Branco, M. M.; Cabrita, A. M. S.; Caramona, M. M.Indomethacin (IM) is a non-steroidal anti-inflammatory drug which inhibits prostaglandin biosynthesis. It is practically insoluble in water and has the capacity to induce gastric injury. Hydroxypropyl-b-cyclodextrin (HP-b-CD) is an alkylated derivative of b-CD with the capacity to form inclusion complexes with suitable molecules. IM is considered to form partial inclusion complexes with HP-b-CD by enclosure of ...
The maximal electroshock seizure (MES) model in the preclinical assessment of p...
Castel-Branco, M. M.; Alves, G. L.; Figueiredo, I. V.; Falcão, Amílcar; Caramona, M. M.The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...
Lamotrigine pharmacokinetic/pharmacodynamic modelling in rats
Castel-Branco, M. M.; Falcão, A. C.; Figueiredo, I. V.; Caramona, M. M.The aim of this study was to perform a pharmacokinetic/pharmacodynamic (PK/PD) modelling of lamotrigine following its acute administration to rats. Adult male Wistar rats were given 10 mg/kg of lamotrigine intraperitoneally. Plasma and brain samples were obtained at predetermined times over 120 h post-dose and analysed by liquid chromatography. The anticonvulsant profile against maximal electroshock seizure sti...
Neuropharmacokinetic characterization of lamotrigine after its acute administra...
Castel-Branco, M. M.; Falcão, A. C.; Figueiredo, I. V.; Caramona, M. M.; Lanao, J. M.3910-3178-31BA | MARIA MARGARIDA COUTINHO DE SEABRA CASTEL-BRANCO CAETANO; info:eu-repo/semantics/publishedVersion