3 documents found, page 1 of 1
Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats...
Neves, C.; Rodrigues, T.; Sereno, J.; Simões, C.; Castelhano, J.; Gonçalves, J.; Bento, G.; Gonçalves, S.; Seiça, R.; Domingues, M. R. M.Nonalcoholic fatty liver disease (NAFLD) is caused by excessive liver lipid accumulation, but insulin resistance is specifically associated with impaired lipid saturation, oxidation, and storage (esterification), besides increased de novo lipogenesis. We hypothesized that dietary glycotoxins could impair hepatic lipid metabolism in obesity contributing to lipotoxicity-driven insulin resistance and thus to the o...
Data driven diagnostic classification in Alzheimer's disease based on different...
Oliveira, Francisco; Leuzy, Antoine; Castelhano, J.; Chiotis, Konstantinos; Hasselbalch, Steen Gregers; Rinne, Juha; Mendonça, Alexandre dePositron emission tomography (PET) neuroimaging with the Pittsburgh Compound_B (PiB) is widely used to assess amyloid plaque burden. Standard quantification approaches normalize PiB-PET by mean cerebellar gray matter uptake. Previous studies suggested similar pons and white-matter uptake in Alzheimer's disease (AD) and healthy controls (HC), but lack exhaustive comparison of normalization across the three regio...
Cortical functional topography of high-frequency gamma activity relates to perc...
Castelhano, J.; Duarte, Isabel C.; Abuhaiba, Sulaiman I.; Rito, Manuel; Sales, Francisco; Castelo-Branco, MiguelHigh-frequency activity (HFA) is believed to subserve a functional role in cognition, but these patterns are often not accessible to scalp EEG recordings. Intracranial studies provide a unique opportunity to link the all-encompassing range of high-frequency patterns with holistic perception. We tested whether the functional topography of HFAs (up to 250Hz) is related to perceptual decision-making. Human intraco...