38 documents found, page 1 of 4
MHC Variants Associated With Symptomatic Versus Asymptomatic SARS-CoV-2 Infecti...
Castelli, Erick C. [UNESP]; de Castro, Mateus V.; Naslavsky, Michel S.; Scliar, Marilia O.; Silva, Nayane S. B. [UNESP]; Andrade, Heloisa S. [UNESP]Made available in DSpace on 2022-04-29T08:46:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-09-28; Center for Information Technology; Center for Scientific Review; National Institutes of Health; Office of Extramural Research, National Institutes of Health; Office of Research Infrastructure Programs, National Institutes of Health; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fu...
HLA-G genetic diversity and evolutive aspects in worldwide populations
Castelli, Erick C. [UNESP]; de Almeida, Bibiana S.; Muniz, Yara C. N.; Silva, Nayane S. B. [UNESP]; Passos, Marília R. S. [UNESP]Made available in DSpace on 2022-04-29T08:46:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01; HLA-G is a promiscuous immune checkpoint molecule. The HLA-G gene presents substantial nucleotide variability in its regulatory regions. However, it encodes a limited number of proteins compared to classical HLA class I genes. We characterized the HLA-G genetic variability in 4640 individuals from 88 di...
Recurrence of COVID-19 associated with reduced T-cell responses in a monozygoti...
De Castro, Mateus V.; Santos, Keity S.; Apostolico, Juliana S.; Fernandes, Edgar R.; Almeida, Rafael R.; Levin, Gabriel; Magawa, Jhosiene Y.Made available in DSpace on 2022-04-29T08:46:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Recurrence of COVID-19 in recovered patients has been increasingly reported. However, the immune mechanisms behind the recurrence have not been thoroughly investigated. The presence of neutralizing antibodies (nAbs) in recurrence/reinfection cases suggests that other types of immune response are involve...
Analysis and comparison of the STR genotypes called with HipSTR, STRait Razor a...
Valle-Silva, Guilherme; Frontanilla, Tamara Soledad; Ayala, Jesús; Donadi, Eduardo Antonio; Simões, Aguinaldo Luiz; Castelli, Erick C. [UNESP]Made available in DSpace on 2022-04-29T08:46:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-05-01; Short tandem repeats (STRs) are particularly difficult to genotype with rapid evolving next-generation sequencing (NGS) technology. Long amplicons containing repetitive sequences result in alignment and genotyping errors. Stutters arising from polymerase slippage often result in reads with additional or...
Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Br...
Naslavsky, Michel S.; Scliar, Marilia O.; Yamamoto, Guilherme L.; Wang, Jaqueline Yu Ting; Zverinova, Stepanka; Karp, Tatiana; Nunes, KellyMade available in DSpace on 2022-04-29T08:46:40Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-12-01; National Institute of General Medical Sciences; As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset of 1,171 highly a...
An immunogenetic view of COVID-19
Aguiar, Vitor R. C.; Augusto, Danillo G.; Castelli, Erick C. [UNESP]; Hollenbach, Jill A.; Meyer, Diogo; Nunes, Kelly; Petzl-Erler, Maria LuizaMade available in DSpace on 2022-04-29T08:32:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; National Institutes of Health; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Meeting the challenges brought by the COVID-19 pandemic requires an interdisciplinary approach. In this context, integrating knowledge of immune function with an understanding of how genetic variation in...
KIR2DL4 genetic diversity in a Brazilian population sample: implications for tr...
Weiss, Emiliana [UNESP]; Andrade, Heloisa S. [UNESP]; Lara, Juliana Rodrigues [UNESP]; Souza, Andreia S. [UNESP]; Paz, Michelle A. [UNESP]Made available in DSpace on 2021-06-25T10:53:00Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-06-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); KIR2DL4 is an important immune modulator expressed in natural killer cells; HLA-G is its main ligand. We have characterized the KIR2DL4 genetic diversity by considering the promoter, all exons, and all introns in a highly admixed Brazilian p...
Relevance of pd-l1 non-coding polymorphisms on the prognosis of a genetically a...
Machado-Rugolo, Juliana [UNESP]; Prieto, Tabatha Gutierrez; Fabro, Alexandre Todorovic; Cuentas, Edwin Roger Parra; Sá, Vanessa KarenMade available in DSpace on 2021-06-25T10:53:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Purpose: Although non-small cell lung cancer (NSCLC) remains a deadly disease, new predictive biomarkers have emerged to assist in managing the disease, of which one of the most promising is the programmed death-ligand 1 (PD-L1). Each, PD-L1...
Peripheral spectrum neurological disorder after arbovirus infection is associat...
Sonon, Paulin; Collares, Cristhianna V.A.; Ferreira, Maria Lúcia Brito; Almeida, Renata Santos; Sadissou, Ibrahim; Cordeiro, Marli TenórioMade available in DSpace on 2021-06-25T10:58:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-08-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação Oswaldo Cruz; Introduction: Non-classical class I human leukocyte antigens (HLA) molecules are known to modulate the function of cytotoxic cells (NK and T C...
Prediction of eye and hair pigmentation phenotypes using the HIrisPlex system i...
Carratto, Thássia Mayra Telles; Marcorin, Letícia; do Valle-Silva, Guilherme; de Oliveira, Maria Luiza Guimarães; Donadi, Eduardo AntônioMade available in DSpace on 2021-06-25T10:58:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-01; Human pigmentation is a complex trait, probably involving more than 100 genes. Predicting phenotypes using SNPs present in those genes is important for forensic purpose. For this, the HIrisPlex tool was developed for eye and hair color prediction, with both models achieving high accuracy among Europeans...