20 documents found, page 1 of 2
Rising trends of urinary infections among pregnant women: Insights from a Portu...
Rodrigues, Francisco; Patricia Coelho; Mateus, Sónia; Eideh, Hatem; Gonçalves, Teresa; Caseiro, Armando; Castelo Branco, MiguelThis study explores the prevalence and antibiotic resistance of urinary tract infections (UTIs) in pregnant women in central Portugal. A retrospective observational study was conducted on 201 positive urine cultures from pregnant women at a hospital center between January 2018 and December 2022. The data collected included age, hospital admission source, history of antibiotic therapy, catheterization status, id...
Decoding urinary tract infection trends: A 5-year snapshot from Central Portugal
Rodrigues, Francisco; Coelho, Patrícia; Patricia Coelho; Mateus, Sónia; Caseiro, Armando; Eideh, Hatem; Gonçalves, Teresa; Castelo Branco, MiguelIntroduction: This study analyzes urinary tract infections (UTIs) in a hospital in Central Portugal over a five-year period, focusing on bacterial prevalence, patient demographics, and antibiotic resistance patterns. This investigation aims to provide insights that can guide improved infection control and treatment strategies. Methods: A total of 6161 positive urine cultures collected over five years were exami...
Investigator-Led Clinical Research in Portugal: Problem Identification and Prop...
Ferreira, João Pedro; Leite-Moreira, Adelino; da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenN/a.; N/a.
Investigação clínica da iniciativa do investigador em Portugal: identificação d...
Ferreira, João Pedro; Leite-Moreira, Adelino; Da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenPortugal tem um problema crónico de subfinanciamento da investigação científica. Apesar do investimento nacional ter vindo a aumentar nos últimos anos, este ainda é manifestamente insuficiente. A Fundação para a Ciência e Tecnologia (FCT) financia anualmente projetos de investigação em todas as áreas científicas, limitando o valor máximo a €250 000 por projeto. Todavia, a área científica na qual a investigação ...
Investigação clínica da iniciativa do investigador em Portugal: identificação d...
Ferreira, João Pedro; Leite-Moreira, Adelino; Da Costa-Pereira, Altamiro; Soares, António José; Robalo-Cordeiro, Carlos; Jerónimo, CármenPortugal tem um problema cronico de subfinanciamento da investigacao cientifica. Apesar do investimento nacional ter vindo a aumentar nos ultimos anos, este ainda e manifestamente insuficiente.1 A Fundacao para a Ciencia e Tecnologia (FCT) financia anualmente projetos de investigacao em todas as areas cientificas, limitando o valor maximo a euro250 000 por projeto. Todavia, a area cientifica na qual a investiga...
Cerebellar morphometric and spectroscopic biomarkers for Machado-Joseph Disease
Miranda, Catarina Oliveira; Nobre, Rui Jorge; Paiva, Vítor Hugo; Duarte, João Valente; Castelhano, João; Petrella, Lorena Itati; Sereno, JoséMachado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) provide promising non-invasive diagnostic and follow-up tools, also serving to evaluate therapies efficacy. However, pre-clinical studies showing relationship between MRI-MRS based biomarkers and functional pe...
Software Bug Detection Causes a Shift From Bottom-Up to Top-Down Effective Conn...
Castelhano, João; Duarte, Isabel C.; Couceiro, Ricardo; Medeiros, Júlio; Durães, João; Afonso, Sónia; Madeira, Henrique; Castelo Branco, MiguelThe neural correlates of software programming skills have been the target of an increasing number of studies in the past few years. Those studies focused on error-monitoring during software code inspection. Others have studied task-related cognitive load as measured by distinct neurophysiological measures. Most studies addressed only syntax errors (shallow level of code monitoring). However, a recent functional...
Trust-Based Decision-Making in the Health Context Discriminates Biological Risk...
Jorge, Helena; Duarte, Isabel C.; Baptista, Carla; Relvas, Ana Paula; Castelo Branco, MiguelSupplementary Materials: The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/jpm12081236/s1, Table S1. Demographic Characteristics, Cognitive results, personality, self-report risk measures and eating behavior for healthy participants; Table S2. Descriptive statistics on economic and health context experimental task for healthy participants; Table S3. Repeated measure...
Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and com...
Canário, Nádia; Jorge, Lília; Martins, Ricardo; Santana, Isabel; Castelo Branco, MiguelThe interplay among neuropathological mechanisms underlying Alzheimer’s disease (AD), as neuroinflammation and amyloid-beta (Aβ), as well their impact on neuronal function remains elusive. A major gap in knowledge is the functional impact of neuroinflammation. The posterior cingulate cortex (PCC), as the most prominent site of amyloid pathology in AD, is a pivotal region to investigate the concomitant presence ...
Cortical inhibition in neurofibromatosis type 1 is modulated by lovastatin, as ...
Bernardino, Inês; Dionísio, Ana; Castelo Branco, MiguelNeurofibromatosis type 1 (NF1) is associated with GABAergic dysfunction which has been suggested as the underlying cause of cognitive impairments. Previous intervention trials investigated the statins' effects using cognitive outcome measures. However, available outcome measures have led to inconclusive results and there is a need to identify other options. Here, we aimed at investigating alternative outcome me...