22 documents found, page 1 of 3
Design and Implementation of a Collaborative Clinical Practice and Research Doc...
Direito, B; Santos, A; Mouga, S; Lima, J; Brás, P; Oliveira, G; Castelo-Branco, MThis paper introduces a prototype for clinical research documentation using the structured information model HL7 CDA and clinical terminology (SNOMED CT). The proposed solution was integrated with the current electronic health record system (EHR-S) and aimed to implement interoperability and structure information, and to create a collaborative platform between clinical and research teams. The framework also aim...
A fundamental distinction in early neural processing of implicit social interpr...
Madeira, N; Martins, R; Valente Duarte, J; Costa, G; Macedo, A; Castelo-Branco, MBackground: Social cognition impairment is a key phenomenon in serious mental disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). Although genetic and neurobiological studies have suggested common neural correlates, here we hypothesized that a fundamental dissociation of social processing occurs at an early level in these conditions. Methods: Based on the hypothesis that key structures in the soci...
Radioembolização de Metástases Hepáticas de Carcinoma Colorretal. Um Estudo Ret...
Costa, M; Ferreira, B; Sousa, M; Costa, N; Castelo-Branco, M; Gonçalves, BIntrodução: O papel da radioembolização (RE) de metástases hepáticas de carcinoma colorretal (mhCCR) permanece indefinido. O presente estudo pretende avaliar os resultados e possíveis fatores de prognóstico da RE nestes pacientes. Metodologia: Foi realizada uma análise retrospetiva de todos os doentes com mhCCR quimiorrefratárias e irressecáveis submetidos a RE numa instituição, desde janeiro de 2011 a março de...
Morphometry and gyrification in bipolar disorder and schizophrenia: A comparati...
Madeira, N; Duarte, JV; Martins, R; Costa, GN; Macedo, A; Castelo-Branco, MSchizophrenia is believed to be a neurodevelopmental disease with high heritability. Differential diagnosis is often challenging, especially in early phases, namely with other psychotic disorders or even mood disorders. such as bipolar disorder with psychotic symptoms. Key pathophysiological changes separating these two classical psychoses remain poorly understood, and current evidence favors a more dimensional...
Impulsive and premeditated aggression in male offenders with antisocial persona...
Azevedo, JC; Vieira-Coelho, M; Castelo-Branco, M; Coelho, R; Figueiredo-Braga, MIntroduction Aggression is a clinical symptom of various psychiatric disorders that can be conceptualised as a physical act towards another person with the intent to cause harm. In antisocial personality disorder (ASPD), aggression is a frequent manifestation that differently compromise therapeutic and prognostic goals according to its impulsive or premeditated categorisation. ASPD is characterised by high leve...
Association between Adipokines and Biomarkers of Alzheimer's Disease: A Cross-S...
Letra, L; Matafome, P; Rodrigues, T; Duro, D; Lemos, R; Baldeiras, I; Patrício, M; Castelo-Branco, M; Caetano, G; Seiça, R; Santana, IBACKGROUND: Adipose tissue dysfunction has been implicated in the pathophysiology of Alzheimer's disease. However, the involvement of adipokines, particularly adiponectin, remains unclear. OBJECTIVE: To compare serum and cerebrospinal fluid (CSF) levels of adiponectin, leptin and leptin-to-adiponectin ratio in patients within the spectrum of Alzheimer's disease and evaluate their relationship with classical bio...
The neural basis of fatigue in multiple sclerosis: A multimodal MRI approach
Novo, AM; Batista, S; Alves, C; d'Almeida, OC; Marques, IB; Macário, C; Santana, I; Sousa, L; Castelo-Branco, M; Cunha, LBACKGROUND: Fatigue is a frequent disabling symptom in multiple sclerosis (MS), but its pathophysiology remains incompletely understood. This study aimed to explore the underlying neural basis of fatigue in patients with MS. METHODS: We enrolled 60 consecutive patients with MS and 60 healthy controls (HC) matched on age, sex, and education. Fatigue was assessed using the Portuguese version of the Modified Fatig...
Endothelial Progenitor Cells influence acute and subacute stroke hemodynamics
Sargento-Freitas, J; Aday, S; Nunes, C; Cordeiro, M; Gouveia, A; Silva, F; Machado, C; Rodrigues, B; Santo, GC; Ferreira, C; Castelo-Branco, MBACKGROUND: Endothelial Progenitor Cells (EPCs) are a circulating stem cell population with in vivo capacity of promoting angiogenesis after ischemic events. Despite the promising preclinical data, their potential integration with reperfusion therapies and hemodynamic evolution of stroke patients is still unknown. Our aim was to determine the association of EPCs with acute, subacute and chronic hemodynamic feat...
Visual and ocular motor function in the atypical form of neurodegeneration with...
Jesus-Ribeiro, J; Farinha, C; Amorim, M; Matos, A; Reis, A; Lemos, J; Castelo-Branco, M; Januário, CBACKGROUND/AIMS: Neurodegeneration with brain iron accumulation (NBIA) type I is a rare disease that can be divided into a classical or atypical variant, according to age of onset and clinical pattern. Neuro-ophthalmological involvement has been documented in the classical variant but only anecdotically in the atypical variant. We sought to describe the visual and ocular motor function in patients with atypical...
Bilateral versus ipsilesional cortico-subcortical activity patterns in stroke s...
Vidal, AC; Banca, P; Pascoal, AG; Santo, GC; Sargento-Freitas, J; Gouveia, A; Castelo-Branco, MBackground Understanding of interhemispheric interactions in stroke patients during motor control is an important clinical neuroscience quest that may provide important clues for neurorehabilitation. In stroke patients, bilateral overactivation in both hemispheres has been interpreted as a poor prognostic indicator of functional recovery. In contrast, ipsilesional patterns have been linked with better motor out...