7 documents found, page 1 of 1
MIBiG 4.0: advancing biosynthetic gene cluster curation through global collabor...
Zdouc, Mitja M.; Blin, Kai; Louwen, Nico L. L.; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D.; Bailey, Constance B.; Barra, LenaSpecialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readabl...
Microalgae and Cyanobacteria Strains as Producers of Lipids with Antibacterial ...
Cepas, Virginio; Gutiérrez-Del-Río, Ignacio; López, Yuly; Redondo-Blanco, Saúl; Gabasa, Yaiza; Iglesias, María José; Soengas, RaquelLipids are one of the primary metabolites of microalgae and cyanobacteria, which enrich their utility in the pharmaceutical, feed, cosmetic, and chemistry sectors. This work describes the isolation, structural elucidation, and the antibiotic and antibiofilm activities of diverse lipids produced by different microalgae and cyanobacteria strains from two European collections (ACOI and LEGE-CC). Three microalgae s...
The Extremophile Endolithella mcmurdoensis gen. et sp. nov. (Trebouxiophyceae, ...
Martins, Teresa P.; Ramos, Vitor; Hentschke, Guilherme S.; Castelo-Branco, Raquel; Rego, Adriana; Monteiro, Maria; Brito, Ângela; Tamagnini, PaulaThe McMurdo Dry Valleys constitute the largest ice-free region of Antarctica and one of the most extreme deserts on Earth. Despite the low temperatures, dry and poor soils and katabatic winds, some microbes are able to take advantage of endolithic microenvironments, inhabiting the pore spaces of soil and constituting photosynthesis-based communities. We isolated a green microalga, Endolithella mcmurdoensis gen....
Inhibition of Bacterial and Fungal Biofilm Formation by 675 Extracts from Micro...
Cepas, Virginio; López, Yuly; Gabasa, Yaiza; Martins, Clara B.; Ferreira, Joana D.; Correia, Maria J.; Santos, Lília M. A.; Oliveira, FlávioBacterial biofilms are complex biological systems that are difficult to eradicate at a medical, industrial, or environmental level. Biofilms confer bacteria protection against external factors and antimicrobial treatments. Taking into account that about 80% of human infections are caused by bacterial biofilms, the eradication of these structures is a great priority. Biofilms are resistant to old-generation anti...
Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Pre...
Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins that relie...
Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Pre...
Costa, Margarida; Sampaio-Dias, Ivo E.; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.Small, single-celled planktonic cyanobacteria are ubiquitous in the world's oceans yet tend not to be perceived as secondary metabolite-rich organisms. Here we report the isolation and structure elucidation of hierridin C, a minor metabolite obtained from the cultured picocyanobacterium Cyanobium sp. LEGE 06113. We describe a simple, straightforward synthetic route to the scarcely produced hierridins that relie...
Cyanobacterial diversity held in microbial biological resource centers as a bio...
Ramos, Vitor; Morais, João; Castelo-Branco, Raquel; Pinheiro, Ângela; Martins, Joana; Regueiras, Ana; Pereira, Ana L.; Lopes, Viviana R.Cyanobacteria are a well-known source of bioproducts which renders culturable strains a valuable resource for biotechnology purposes. We describe here the establishment of a cyanobacterial culture collection (CC) and present the first version of the strain catalog and its online database (http://lege.ciimar.up.pt/). The LEGE CC holds 386 strains, mainly collected in coastal (48%), estuarine (11%), and fresh (34...