7 documents found, page 1 of 1
An integrative sialomic analysis reveals molecules from Triatoma sordida (Hemip...
Praça, Yanna Reis; Santiago, Paula Beatriz; Charneau, Sébastien; Mandacaru, Samuel Coelho; Bastos, Izabela Marques Dourado; Bentes, Kaio Luís da SilvaTriatomines have evolved salivary glands that produce versatile molecules with various biological functions, including those leading their interactions with vertebrate hosts’ hemostatic and immunological systems. Here, using high-throughput transcriptomics and proteomics, we report the first sialome study on the synanthropic triatomine Triatoma sordida. As a result, 57,645,372 reads were assembled into 26,670 c...
Proteomic mapping of multifunctional complexes within Triatomine saliva
Santiago, Paula Beatriz; Charneau, Sébastien; Mandacaru, Samuel Coelho; Bentes, Kaio Luís da Silva; Bastos, Izabela Marques DouradoTriatomines are hematophagous insects that transmit Trypanosoma cruzi, the etiological agent of Chagas disease. This neglected tropical disease represents a global health issue as it is spreading worldwide. The saliva of Triatominae contains miscellaneous proteins crucial for blood feeding acquisition, counteracting host's hemostasis while performing vasodilatory, anti-platelet and anti-coagulant activities, be...
Triatomines : trypanosomatids, bacteria, and viruses potential vectors?
Vieira, Caroline Barreto; Praça, Yanna Reis; Bentes, Kaio Luís da Silva; Santiago, Paula Beatriz; Silva, Sofia Marcelino MartinsTriatominae bugs are the vectors of Chagas disease, a major concern to public health especially in Latin America, where vector-borne Chagas disease has undergone resurgence due mainly to diminished triatomine control in many endemic municipalities. Although the majority of Triatominae species occurs in the Americas, species belonging to the genus Linshcosteus occur in India, and species belonging to the Triatom...
Descrição extensiva dos sialomas de Rhodnius neglectus e Triatoma dimidiata, ve...
Santiago, Paula BeatrizTese (doutorado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médicas, 2016.; Programa de apoio a Núcleos de excelência (PRONEX); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação de Apoio à Pesquisa do Distrito Federal (FAP-DF); Financiadora de Estudos e Projetos (FINEP).;...
Proteases of haematophagous arthropod vectors are involved in blood-feeding, yo...
Santiago, Paula Beatriz; Araújo, Carla Nunes de; Motta, Flávia Nader; Praça, Yanna Reis; Charneau, Sébastien; Bastos, Izabela Marques DouradoTicks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous arthropods considered vectors of human infectious diseases. While consuming blood to obtain the nutrients necessary to carry on life functions, these insects can transmit pathogenic microorganisms to the vertebrate host. Among the molecules related to the blood-feeding habit, proteases play an essential role. In this review,...
A Deep Insight into the Sialome of Rhodnius neglectus, a vector of chagas disease
Santiago, Paula Beatriz; Assumpção, Teresa Cristina França de; Araújo, Carla Nunes de; Bastos, Izabela Marques Dourado; Neves, DavidBackground Triatomines are hematophagous insects that act as vectors of Chagas disease. Rhodnius neglectus is one of these kissing bugs found, contributing to the transmission of this American trypanosomiasis. The saliva of hematophagous arthropods contains bioactive molecules responsible for counteracting host haemostatic, inflammatory, and immuneresponses. Methods/Principal Findings Next generation sequencing...
Análise proteômica revela que a saliva de Dipetalogaster maxima é rica em lipoc...
Santiago, Paula BeatrizDissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, 2011.; A pesquisa em doença de Chagas acumula bons resultados no que se refere à transmissão do Trypanosoma cruzi. Contudo, fatores devem ser considerados: a ocupação humana de áreas naturalmente habitadas por esses insetos e a presença constante do T. cruzi em populações animais aumentam o risco de novas transmissões ao homem. Esse cenário...