16 documents found, page 1 of 2
Enhancement of the solubility of 5-fluorouracil through encapsulation within β-...
Machado, Mónica; Silva, Gabriela A.; Ferreira, Joana; Pinto, Luís Abegão; Ferreira, QuirinaThis journal is © The Royal Society of Chemistry.; 5-Fluorouracil (5-FU) is an antimetabolite agent used in chemotherapy and wound healing management, with low solubility and bioavailability. To overcome these challenges, this study explores the encapsulation of 5-FU within β-cyclodextrin (β-CD). The inclusion complex was prepared using the solubilization process, and its stability was evaluated under a variety...
The pleural mesothelioma cases and mortality in portugal in 2014–2020
Santos, Cátia; Sacadura-Leite, Ema; Ferreira, Joana; Dixe, Maria dos Anjos; Astoul, Philippe; Sousa-Uva, AntónioPublisher Copyright: © 2024 by the authors.; Background: The incidence and mortality of pleural mesothelioma (PM) reflect the production and consumption of asbestos over time. However, despite the current global concern, these data remain to be known. Objective: Our aim was to carry out a descriptive analysis of PM cases and mortality from some Portuguese databases between 2014 and 2020. Methods: A retrospectiv...
Investigating the association between ambient particulate matter (PM10) exposur...
Gaio, Vânia; Roquette, Rita; Monteiro, Alexandra; Ferreira, Joana; Matias Dias, Carlos; Nunes, BaltazarCopyright © 2023 Sociedade Portuguesa de Cardiologia. Publicado por Elsevier España, S.L.U. All rights reserved.; INTRODUCTION AND OBJECTIVES: High blood pressure (BP) remains a major modifiable cardiovascular (CV) risk factor. Several epidemiologic studies have been performed to assess the association between air pollution exposure and this CV risk factor but results remain inconsistent. This study aims to est...
Genetic Contribution of the Adrenergic, Cholinergic, and Serotonergic Systems t...
Inácio, Ângel; Aguiar, Laura; Carrilho, Raquel; Pires, Patrícia; Ferreira, Joana; Coelho, Luís; Mascarenhas, Mário Rui; Sardinha, Luís; Bilhim, TiagoFunding Information: study, we conclude that the ADBR2 and CHRNA5 genes have a relevant role in the development of leiomyoma. This role appears to be enhanced by the epistatic relationship with the genes HTR2A and SLC6A4. This study, confirms the involvement of the Autonomous Nervous System in tumor biology, along with the genetics of the mechanisms, involved in chronic stress. By highlighting and helping to el...
Schwannoma mimicking ovarian malignancy
Conde Vasco, Inês; Martins Pereira, Gonçalo; Ferreira, Joana; Cunha, Teresa MargaridaIn this article, we present a case of retroperitoneal schwannoma localized in the pelvic cavity mimicking ovarian carcinoma. A 60-year-old woman presented with a feeling of pelvic heaviness and dyspareunia for 3 months. On physical examination, a hardened mass is palpated on the cul-de-sac of Douglas, measuring approximately 10 cm. The sonographic study showed a retro-uterine solid mass, containing cystic areas...
PM10 exposure interacts with abdominal obesity to increase blood triglycerides
Gaio, Vânia; Roquette, Rita; Monteiro, Alexandra; Ferreira, Joana; Lopes, Diogo; Dias, Carlos Matias; Nunes, Baltazar© The Author(s) 2021. Published by Oxford University Press on behalf of the European Public Health Association. All rights reserved.; BACKGROUND: Blood lipids and glucose levels dysregulation represent potential mechanisms intermediating the adverse cardiovascular effects of ambient particulate matter (PM) exposure. This study aims to estimate the effect of long-term PM10 exposure on blood lipids and glucose le...
Descriptive Analysis of Adverse Drug Reactions Reports of the Most Consumed Ant...
Ferreira, Joana; Placido, Ana Isabel; Afreixo, Vera; Ribeiro-Vaz, Ines; Roque, Fatima; Herdeiro, Maria TeresaFunding: This research was funded by the project PTDC/SAU-SER/31678/2017, supported by the Operational Program on Competitiveness and Internationalization (POCI) in its FEDER/FNR component, POCI-01-0145-FEDER-031678, and by the Foundation for Science and Technology in its state budget component (OE).; Adverse drug reactions (ADR) significantly impact mortality and morbidity and lead to high healthcare costs. Re...
P16 and hpv genotype significance in hpv-associated cervical cancer-a large coh...
da Mata, Sara; Ferreira, Joana; Nicolás, Inmaculada; Esteves, Susana; Esteves, Gonçalo; Lérias, Sofia; Silva, Fernanda; Saco, Adela; Cochicho, DanielaThe expression of p16 is a good surrogate of human papillomavirus (HPV) infection in HPV-associated cancers. The significance of p16 expression, HPV genotype and genera in the outcome of patients with HPV-associated cervical cancer (CC) is unclear. Our aim is to ascertain the prognostic significance of these factors. Data from 348 patients (median age: 47.5 years old) with CC, diagnosed in two referral centers,...
Differences in the genotype frequencies of genes related to blood pressure regu...
Aguiar, Laura; Semente, Ildegário; Ferreira, Joana; Carvalho, Andreia; Silva, Alda P.; Caroça, Cristina; Caria, Helena; Damasceno, AlbertinoFunding Information: The authors are grateful to all study participants and would like to thank the Instituto de Investiga??o Cient?fica Bento da Rocha Cabral for financial support. Publisher Copyright: © 2021 Aguiar L et al.; Background: Since the emergence of the genus Homo, hominids have occupied a wide variety of environments, facing different selective pressures. Objectives: The aim this study is to compar...
Exposure to ambient particulate matter increases blood count parameters with po...
Gaio, Vânia; Roquette, Rita; Monteiro, Alexandra; Ferreira, Joana; Rafael, Sandra; Dias, Carlos Matias; Nunes, BaltazarVariations in blood count parameters are potential mechanisms involved in the occurrence of cardiovascular events caused by particulate matter (PM) exposure. This study aims to estimate the effect of PM10 exposure on blood count parameters with potential to mediate a cardiovascular event. We used data from 2211 participants of the 1st Portuguese Health Examination Survey (INSEF, 2015) with available information...