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Prospective Observational Study on acute Appendicitis Worldwide (POSAW)

Sartelli, M; Baiocchi, GL; Di Saverio, S; Ferrara, F; Labricciosa, FM; Ansaloni, L; Coccolini, F; Vijayan, D; Abbas, A; Abongwa, HK; Agboola, J

BACKGROUND: Acute appendicitis (AA) is the most common surgical disease, and appendectomy is the treatment of choice in the majority of cases. A correct diagnosis is key for decreasing the negative appendectomy rate. The management can become difficult in case of complicated appendicitis. The aim of this study is to describe the worldwide clinical and diagnostic work-up and management of AA in surgical departme...


Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases...

Castro, P; Santos, M; Freitas, S; Cana-Quijada, P; Lourenço, T; Rodrigues, M; Fonseca, F; Ruiz-Albert, J; Azevedo, JE; Tavares, R; Castillo, A

Post-translational modifiers such as the small ubiquitin-like modifier (SUMO) peptide act as fast and reversible protein regulators. Functional characterization of the sumoylation machinery has determined the key regulatory role that SUMO plays in plant development. Unlike components of the SUMO conjugation pathway, SUMO proteases (ULPs) are encoded by a relatively large gene family and are potential sources of...


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