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IFN-gamma-dependent activation of macrophages during experimental infections by...
Torrado, Egídio; Fraga, Alexandra Gabriel; Logarinho, Elsa; Martins, Teresa G.; Carmona, Jenny A.; Gama, José B.; Carvalho, Maria A.Buruli ulcer, caused by Mycobacterium ulcerans infections, is a necrotizing skin disease whose pathogenesis is associated with the exotoxin mycolactone. Despite the relevance of this emergent disease, little is known on the immune response against the pathogen. Following the recent demonstration of an intramacrophage growth phase for M. ulcerans, we investigated the biological relevance of IFN-gamma and the ant...
Date: 2010
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Origin: RepositóriUM - Universidade do Minho