5 documents found, page 1 of 1
Antimicrobial, Antibiofilm, and Antioxidant Properties of Boletus edulis and Ne...
Garcia, Juliana; Rodrigues, Francisca; Castro, Flávia; Aires, Alfredo; Marques, Guilhermina; Saavedra, Maria JoséMultidrug-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) has become the most recurrent global cause of skin and soft-tissue infections, belonging to the WHO priority pathogens list. Successful therapy remains challenging and entails the assessment of novel and successful antibiotics. In th...
Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Ca...
Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, Ana Patrícia; Castro, Flávia; Sousa, Bárbara; Pinto, Marta LaranjeiroIn colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage-cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...
Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in...
Castro, Flávia; Pinto, Marta L.; Pereira, Catarina L.; Serre, Karine; Barbosa, Mário A.; Vermaelen, Karim; Gärtner, Fátima; Gonçalves, Raquel M.Radiotherapy (RT) is an essential treatment modality for several types of cancer. Despite its therapeutic potential, RT is frequently insufficient to overcome the immunosuppressive nature of the tumor microenvironment, failing to control tumor metastases. Innovative immunomodulatory strategies, like immunostimulatory biomaterials could be used to boost the immunogenic effects of RT. Herein, we addressed the syn...
Interferon-gamma at the crossroads of tumor immune surveillance or evasion
Castro, Flávia; Cardoso, Ana Patrícia; Gonçalves, Raquel Madeira; Serre, Karine; Oliveira, Maria JoséInterferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major effector of immunity, has been used in the treatment of several diseases, despite its adverse effects. Although broad evidence implicating IFN-γ in tumor immune surveillance, IFN-γ-based therapies undergoing clinical trials have been of...
Type I IFN inhibits alternative macrophage activation during mycobacterium tube...
Moreira-Teixeira, Lúcia; Sousa, Jeremy Nicolas Carvalho; McNab, Finlay W.; Torrado, Egídio; Cardoso, Filipa; Machado, Henrique; Castro, FláviaTuberculosis causes ∼1.5 million deaths every year, thus remaining a leading cause of death from infectious diseases in the world. A growing body of evidence demonstrates that type I IFN plays a detrimental role in tuberculosis pathogenesis, likely by interfering with IFN-γ–dependent immunity. In this article, we reveal a novel mechanism by which type I IFN may confer protection against Mycobacterium tuberculos...