20 documents found, page 1 of 2
Π-Π stacking stabilized polymeric micelles for hydrophobic drug delivery in the...
Alves, Ana G. Gomes; Varela-Moreira, Aida; Cruz, Tânia; Duarte, Margarida; Castro, Helena; Moreira, Rui; Ressurreição, Ana S.; Storm, GertCurrent control strategies for leishmaniases − a group of diseases caused by protozoan parasites of the genus Leishmania − rely on chemotherapy, which is often associated with significant drawbacks, including severe side effects and limited drug efficacy. The public health impact of leishmaniases underscores the urgent need for new therapeutic approaches. Quinoline-(1H)-imines have emerged as promising lead com...
Unforeseen plant phenotypic diversity in a dry and grazed world
Gross, Nicolas; Maestre, Fernando T.; Liancourt, Pierre; Berdugo, Miguel; Martin, Raphaël; Gozalo, Beatriz; Ochoa, Victoria; Delgado-Baquerizo, ManuelEarth harbours an extraordinary plant phenotypic diversity1 that is at risk from ongoing global changes2,3. However, it remains unknown how increasing aridity and livestock grazing pressure—two major drivers of global change4,5,6—shape the trait covariation that underlies plant phenotypic diversity1,7. Here we assessed how covariation among 20 chemical and morphological traits responds to aridity and grazing pr...
Drivers of woody dominance across global drylands
Biancari, Lucio; Aguiar, Martín R.; Eldridge, David J.; Oñatibia, Gastón R.; Le Bagousse-Pinguet, Yoann; Saiz, Hugo; Gross, Nicolas; Austin, Amy T.Increases in the abundance of woody species have been reported to affect the provisioning of ecosystem services in drylands worldwide. However, it is virtually unknown how multiple biotic and abiotic drivers, such as climate, grazing, and fire, interact to determine woody dominance across global drylands. We conducted a standardized field survey in 304 plots across 25 countries to assess how climatic features, ...
Functional Groups Response to Water Deficit in Mediterranean Ecosystems
Castro, Helena; Dias, Maria Celeste; Sousa, José Paulo; Freitas, HelenaEnhanced drought, more frequent rainfall events and increased inter-annual variability of precipitation are the main trends of climate expected for the Mediterranean. Drought is one of the most important stressors for plants and significantly impacts plant communities causing changes in plant composition and species dominance. Through an experiment under controlled conditions, we assessed the response of Medite...
Impact of genome duplications in drought tolerance and distribution of the dipl...
Castro, Helena; Dias, Maria Celeste; Castro, Mariana; Loureiro, João; Castro, SilviaPolyploidy has important ecological effects, including ploidy-mediated effects on morphology, breeding system and ecological tolerances. However, there is still little comprehensive research available to test its adaptive significance and its role in driving distributional patterns. This work aimed to assess the contribution of genome duplications to ecological divergence using an experimental approach with the...
Video abstract production guide
Ferreira, Miguel; Lopes, Betina; Granado, António; Siopa, Catarina; Gaspar, Hugo; Castro, Helena; Castro, Silvia; Loureiro, JoãoVideo abstracts are audio-visual representations of a scientific abstract that a researcher can use to complement an article. As a science communication tool, they stand as a novel and exciting way to present scientific discoveries, explore new formats, and reach new audiences. In this practice insight, we share the experience of creating a video abstract in Ecology, explaining and exemplifying the dierent stag...
Video abstract production guide
Ferreira, Miguel; Lopes, Betina; Granado, António; Siopa, Catarina; Gaspar, Hugo; Castro, Helena; Castro, Sílvia; Loureiro, JoãoVideo abstracts are audio-visual representations of a scientific abstract that a researcher can use to complement an article. As a science communication tool, they stand as a novel and exciting way to present scientific discoveries, explore new formats, and reach new audiences. In this practice insight, we share the experience of creating a video abstract in Ecology, explaining and exemplifying the different st...
MigraR: An open-source, R-based application for analysis and quantification of ...
Shaji, Nirbhaya; Nunes, Florbela; Rocha, M Ines; Gomes, Elsa Ferreira; Castro, HelenaCell migration is essential for many biological phenomena with direct impact on human health and disease. One conventional approach to study cell migration involves the quantitative analysis of individual cell trajectories recorded by time-lapse video microscopy. Dedicated software tools exist to assist the automated or semi-automated tracking of cells and translate these into coordinate positions along time. H...
Grazing and ecosystem service delivery in global drylands
Maestre, Fernando T.; Le Bagousse-Pinguet, Yoann; Delgado-Baquerizo, Manuel; Eldridge, David J.; Saiz, Hugo; Berdugo, Miguel; Gozalo, BeatrizGrazing represents the most extensive use of land worldwide. Yet its impacts on ecosystem services remain uncertain because pervasive interactions between grazing pressure, climate, soil properties, and biodiversity may occur but have never been addressed simultaneously. Using a standardized survey at 98 sites across six continents, we show that interactions between grazing pressure, climate, soil, and biodiver...
Quinolin-(1H)-imines as a new chemotype against leishmaniasis: biological evalu...
Alves, Ana G. Gomes; Duarte, Margarida; Cruz, Tânia; Castro, Helena; Lopes, Francisca; Moreira, Rui; Ressurreição, Ana S.; Tomás, Ana M.Leishmaniasis is one of the most challenging neglected tropical diseases and remains a global threat to public health. Currently available therapies for leishmaniases present significant drawbacks and are rendered increasingly inefficient due to parasite resistance, urging the need for more effective, safer, and cheaper drugs. In our efforts to identify novel chemical scaffolds for the development of antileishm...