13 documents found, page 1 of 2

Thioredoxin Reductase Inhibitors as Potential Antitumors: Mercury Compounds Eff...

Glioblastoma multiforme (GBM) is the most aggressive and common form of glioma. GBM, like many other tumors, expresses high levels of redox proteins, such as thioredoxin (Trx) and thioredoxin reductase (TrxR), allowing tumor cells to cope with high levels of reactive oxygen species (ROS) and resist chemotherapy and radiotherapy. Thus, tackling the activity of these enzymes is a strategy to reduce cell viability...

N-Acetylcysteine or Sodium Selenite Prevent the p38-Mediated Production of Proi...

Mercury (Hg) is known for its neurotoxicity and is reported to activate microglia cells at low exposure levels. Since mercury decreases the activity of the glutathione and thioredoxin systems, we hypothesize that Hg would, in turn, disrupt microglia homeostasis by interfering with redox regulation of signaling pathways. Thus, in this work, we analyzed the effect of exposure to Hg2+ on nuclear translocation and ...

N-acetylcysteine or sodium selenite prevent the p38-mediated production of proi...

Mercury (Hg) is known for its neurotoxicity and is reported to activate microglia cells at low exposure levels. Since mercury decreases the activity of the glutathione and thioredoxin systems, we hypothesize that Hg would, in turn, disrupt microglia homeostasis by interfering with redox regulation of signaling pathways. Thus, in this work, we analyzed the effect of exposure to Hg2+ on nuclear translocation and ...

Thioredoxin reductase inhibitors as potential antitumors : mercury compounds ef...

Glioblastoma multiforme (GBM) is the most aggressive and common form of glioma. GBM, like many other tumors, expresses high levels of redox proteins, such as thioredoxin (Trx) and thioredoxin reductase (TrxR), allowing tumor cells to cope with high levels of reactive oxygen species (ROS) and resist chemotherapy and radiotherapy. Thus, tackling the activity of these enzymes is a strategy to reduce cell viability...

Toxic metal exposure as a possible risk factor for COVID-19 and other respirato...

Made available in DSpace on 2021-06-25T10:14:13Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-12-01; Ministry of Science and Higher Education of the Russian Federation; Deutsche Forschungsgemeinschaft; National Institute of Environmental Health Sciences; Multiple medical, lifestyle, and environmental conditions, including smoking and particulate pollution, have been considered as risk factors for COron...

Evaluating the risk of manganese-induced neurotoxicity of parenteral nutrition:...

High throughput fluorimetric assessment of iron traffic and chelation in iron-o...

Behavioral effects of developmental methylmercury drinking water exposure in ro...

Anthocyanin-Rich Açaí (Euterpe oleracea Mart.) extract attenuates manganese-ind...

Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures

Chronic exposure to excessive levels of Mn results in a movement disorder termed manganism, which resembles Parkinson's disease (PD). The pathogenic mechanisms underlying this disorder are not fully understood. Several lines of evidence implicate astrocytes as an early target of Mn neurotoxicity. In the present study, we investigated the effects of Mn on mitochondrial function. Primary astrocyte cultures were p...