4 documents found, page 1 of 1
Central acting hsp10 regulates mitochondrial function, fatty acid metabolism, a...
Wardelmann, K; Rath, M; Castro, JP; Blümel, S; Schell, M; Hauffe, R; Schumacher, F; Flore, T; Ritter, K; Wernitz, A; Hosoi, T; Ozawa, K; Kleuser, BMitochondria are critical for hypothalamic function and regulators of metabolism. Hypothalamic mitochondrial dysfunction with decreased mitochondrial chaperone expression is present in type 2 diabetes (T2D). Recently, we demonstrated that a dysregulated mitochondrial stress response (MSR) with reduced chaperone expression in the hypothalamus is an early event in obesity development due to insufficient insulin s...
Hepatic wnt1 inducible signaling pathway protein 1 (WISP-1/CCN4) associates wit...
Pivovarova-Ramich, O; Loske, J; Hornemann, S; Markova, M; Seebeck, N; Rosenthal, A; Klauschen, F; Castro, JP; Buschow, R; Grune, T; Lange, VLiver fibrosis is a critical complication of obesity-induced fatty liver disease. Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4), a novel adipokine associated with visceral obesity and insulin resistance, also contributes to lung and kidney fibrosis. The aim of the present study was to investigate the role of CCN4 in liver fibrosis in severe obesity. For this, human liver biopsies were collected from 3...
(In)Fertility and Oxidative Stress: New Insights into Novel Redox Mechanisms Co...
Silva, E; Almeida, H; Castro, JP
Non-enzymatic cleavage of Hsp90 by oxidative stress leads to actin aggregate fo...
Castro, JP; Fernando, R; Reeg, S; Meinl, W; Almeida, H; Grune, TAging is accompanied by the accumulation of oxidized proteins. To remove them, cells employ the proteasomal and autophagy-lysosomal systems; however, if the clearance rate is inferior to its formation, protein aggregates form as a hallmark of proteostasis loss. In cells, during stress conditions, actin aggregates accumulate leading to impaired proliferation and reduced proteasomal activity, as observed in cellu...