3 documents found, page 1 of 1
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer c...
Cátia S. Pereira; Guedes, J.; Gonçalves, Marília; Loureiro, Luís; Castro, Lisandra; Gerós, H.; Rodrigues, L. R.; Côrte-Real, ManuelaBreast cancer is the most common cancer in women worldwide. Metastatic breast cancer cells are known to display V-H+-ATPase at the plasma membrane, where it is involved in the acquisition of a more metastatic phenotype. Therefore, V-H+-ATPase emerged as a promising candidate for breast cancer therapy, and inhibitors of this pump as potential anticancer drugs. Lactoferrin (Lf) is a natural pro-apoptotic glycopro...
Lactoferrin selectively triggers apoptosis in highly metastatic breast cancer c...
Pereira, Cátia S.; Guedes, J.; Gonçalves, Marília; Loureiro, Luís; Castro, Lisandra; Gerós, Hernâni; Rodrigues, L. R.; Côrte-Real, ManuelaBreast cancer is the most common type of cancer affecting women. Despite the good prognosis when detected early, significant challenges remain in the treatment of metastatic breast cancer. The recruitment of the vacuolar H+-ATPase (V-H+-ATPase) to the plasma membrane, where it mediates the acidification of the tumor microenvironment (TME), is a recognized feature involved in the acquisition of a metastatic phen...
Colorectal cancer-related mutant KRAS alleles function as positive regulators o...
Alves, Sara; Castro, Lisandra; Fernandes, Maria Sofia; Francisco, Rita; Castro, Paula; Priault, Muriel; Chaves, Susana Rodrigues; Moyer, Mary PatThe recent interest to modulate autophagy in cancer therapy has been hampered by the dual roles of this conserved catabolic process in cancer, highlighting the need for tailored approaches. Since RAS isoforms have been implicated in autophagy regulation and mutation of the KRAS oncogene is highly frequent in colorectal cancer (CRC), we questioned whether/how mutant KRAS alleles regulate autophagy in CRC and its...