1 document found, page 1 of 1
Sort by
Issue Date
Double-blind clinical trial of arginine supplementation in the treatment of adu...
Eleutério, Renata Mirian Nunes; Nascimento, Francisco O.; Araújo, Tamara G.; Castro, Marilena F.; Almeida Filho, Tarcísio Paulo de; Maia Filho, Pedro A.Background. Sickle cell anaemia (SCA) is the most prevalentmonogenic disease in Brazil. In SCA, haemoglobin S (HbS) is formed, whichmodifies red blood cell morphology. Intravascular haemolysis occurs, in which free Hb and free radicals degrade nitric oxide (NO) and release arginase, which reduces arginine levels. Because arginine is a substrate for NO formation, this decrease leads to reduced NO (vasodilator) s...
Date: 2019
|
Origin: Oasisbr