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Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of imme...

Gaspar, M. C.; Grégoire, N.; Sousa, João J. S.; Pais, Alberto A. C. C.; Lamarche, I.; Gobin, P.; Olivier, J.-C.; Marchand, S.; Couet, W.

A comparative pharmacokinetic study was conducted in rats after intratracheal aerosolization of levofloxacin, as a solution, as immediate-release chitosan microspheres or as sustained-release PLGA microspheres. A pharmacokinetic model was constructed to model levofloxacin concentrations both in plasma and in the lung epithelial lining fluid (ELF). The plasma and ELF experimental concentration profiles versus ti...

Date: 2016   |   Origin: Estudo Geral - Universidade de Coimbra
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