9 documents found, page 1 of 1
CariesCare International adapted for the pandemic in children: Caries OUT multi...
Martignon, S; Cortes, A; Douglas, GVA; Newton, JT; Pitts, NB; Avila, V; Usuga-Vacca, M; Gamboa, LF; Deery, C; Abreu-Placeres, N; Bonifacio, C; Braga, MMBackground: Comprehensive caries care has shown effectiveness in controlling caries progression and improving health outcomes by controlling caries risk, preventing initial-caries lesions progression, and patient satisfaction. To date, the caries-progression control effectiveness of the patient-centred risk-based CariesCare International (CCI) system, derived from ICCMS™ for the practice (2019), remains unprove...
Evaluation of cerebral microvascular regulatory mechanisms with transcranial do...
Castro, P; Gutierres, M; Pereira, G; Ferreira, S; Oliveira, JP; Azevedo, EBackground: Fabry disease (FD) causes cerebrovascular disease (CVD) even if asymptomatic, and this is why it is important to identify non-invasive methods to monitor the disease. We evaluated the usefulness of the cerebral autoregulation, vasoreactivity, and neurovascular coupling assessed by transcranial Doppler (TCD) in FD. Methods: Ten adult patients with classic phenotype FD, without clinical expression of ...
Arabidopsis thaliana SPF1 and SPF2 are nuclear-located ULP2-like SUMO proteases...
Castro, P; Santos, M; Freitas, S; Cana-Quijada, P; Lourenço, T; Rodrigues, M; Fonseca, F; Ruiz-Albert, J; Azevedo, JE; Tavares, R; Castillo, APost-translational modifiers such as the small ubiquitin-like modifier (SUMO) peptide act as fast and reversible protein regulators. Functional characterization of the sumoylation machinery has determined the key regulatory role that SUMO plays in plant development. Unlike components of the SUMO conjugation pathway, SUMO proteases (ULPs) are encoded by a relatively large gene family and are potential sources of...
Ionizing radiation modulates human macrophages towards a pro-inflammatory pheno...
Pinto, AT; Pinto, ML; Cardoso, AP; Monteiro, C; Pinto, MT; Maia, AF; Castro, P; Figueira, R; Monteiro, A; Marques, M; Mareel, M; Santos, S; Seruca, RIn order to improve the efficacy of conventional radiotherapy, attention has been paid to immune cells, which not only modulate cancer cell response to therapy but are also highly recruited to tumours after irradiation. Particularly, the effect of ionizing radiation on macrophages, using therapeutically relevant doses, is not well understood. To evaluate how radiotherapy affects macrophage behaviour and macroph...
Frequency of TERT promoter mutations in human cancers
Vinagre, J; Almeida, A; Pópulo, H; Batista, R; Lyra, J; Pinto, V; Coelho, R; Celestino, R; Prazeres, H; Lima, L; Melo, M; Rocha, AG; Preto, A; Castro, PReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...
Follicular thyroid carcinoma with an unusual glomeruloid pattern of growth.
Cameselle-Teijeiro, J; Pardal, F; Eloy, C; Ruiz-Ponte, C; Celestino, R; Castro, P; Soares, P; Sobrinho-Simões, MWe describe an uncommon thyroid tumor in a 56-year-old woman. The widely infiltrating, angioinvasive neoplasm, 5 cm in diameter, exhibited a peculiar architectural growth pattern characterized by follicles with round to oval epithelial tufts growing within, often supported by a fibrovascular core mimicking the renal glomerulus. Colloid-empty follicles, tubular or elongated, were lined by pseudostratified tall, ...
A Diabetes Mellitus e suas Complicações. Relembrar para Prevenir
Pereira, C; Lourenço, F; Castro, P; Rola, J; Jacquet, JApós breve referência aos principais programas de controlo das complicações da Diabetes Mellitus (Diabetes Control and Complications Trial, Declaração de St. Vincent, DiabCare), apresentam-se algumas propostas de revisão da sua classificação e dos critérios de diagnóstico. Abordam-se alguns conceitos actuais da sua fisiopatologia, descrevendo-se em seguida cada uma das suas complicações com ênfase nos aspectos ...
Murine typhus in Portugal.
André, E; Correia, R; Castro, P; Neto, M; Rola, J; Bacelar, F; Oliveira, I; Velosa, I; Feio, A; Filipe, AMurine typhus or endemic typhus is a wide spread infectious disease, with a low prevalence in developed countries, but surely underdiagnosed. Its relative benignity, the similarity to other infectious diseases and the discretion of its epidemiologic chain, as well as the usual unexpectedness of its existence, makes its diagnosis more difficult. The clinical presentation and evolution of this case illustrate the...
Tifo Murino em Portugal
André, E; Correia, R; Castro, P; Neto, M; Rola, J; Bacelar, F; Oliveira, I; Velosa, I; Feio, A; Filipe, AMurine typhus or endemic typhus is a wide spread infectious disease, with a low prevalence in developed countries, but surely underdiagnosed. Its relative benignity, the similarity to other infectious diseases and the discretion of its epidemiologic chain, as well as the usual unexpectedness of its existence, makes its diagnosis more difficult. The clinical presentation and evolution of this case illustrate the...