12 documents found, page 1 of 2

Outcomes Of Surgically Treated N2-Positive Non-Small Cell Lung Cancer

Introduction: The role of surgery in the treatment of stage IIB/IIIA lung cancer is still a matter of debate. To assess the outcomes of N2-positive patients, we performed a retrospective 10-year study including all patients with histologically proven N2 disease submitted to lung resection surgery by the same surgical team in three different hospitals. Materials and Methods: Demographic, clinical, surgical and s...

The role of the primary health care nurse in promoting active aging: scoping re...

O papel do enfermeiro de cuidados de saúde primários na promoção do envelhecime...

Use of heart rate monitors to measure heart rate variability at rest: a literat...

The Heart Rate Variability (HRV) is a non-invasive method to estimate the cardiac autonomic control that can be measured through the electrocardiogram (ECG), the gold standard method. Portable devices that are more practical and cheaper than ECG, such as heart rate monitors, are a more convenient alternative for measuring HRV in clinical practice, but it is necessary that their results be validated in different...

SAFETY AND RISK FACTORS FOR THE MORBIDITY AND MORTALITY OF PNEUMONECTOMY: A RET...

Objectives: Pneumonectomy is a procedure with high post-operative morbidity and mortality. This study aims to assess and identify possible risk factors that can affect post-operative outcome, therefore determining the safety of pneumonectomy in specific groups. Methods: A total of 63 patients submitted to pneumonectomy at our centre, from February 2008 to February 2018, were included in our retrospective study....

A utilização de recursos não formais no ensino do Estudo do Meio no 1º ciclo do...

TERT promoter mutations are a major indicator of poor outcome in differentiated...

Context: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTCs). De...

Immunohistochemical molecular phenotypes of gastric cancer based on SOX2 and CD...

Background Gastric cancer remains a serious health concern worldwide. Patients would greatly benefit from the discovery of new biomarkers that predict outcome more accurately and allow better treatment and follow-up decisions. Here, we used a retrospective, observational study to assess the expression and prognostic value of the transcription factors SOX2 and CDX2 in gastric cancer. Methods SOX2, CDX2, MUC5AC a...

SERPINA2 is a novel gene with a divergent function from SERPINA1

Serine protease inhibitors (SERPINs) are a superfamily of highly conserved proteins that play a key role in controlling the activity of proteases in diverse biological processes. The SERPIN cluster located at the 14q32.1 region includes the gene coding for SERPINA1, and a highly homologous sequence, SERPINA2, which was originally thought to be a pseudogene. We have previously shown that SERPINA2 is expressed in...

Frequency of TERT promoter mutations in human cancers

Reactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...