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Tauroursodeoxycholic acid prevents E22Q Alzheimer's A beta toxicity in human ce...

Viana, R. J. S.; Nunes, A. F.; Castro, R. E.; Ramalho, R. M.; Meyerson, J.; Fossati, S.; Ghiso, J.; Rostagno, A.; Rodrigues, C. M. P.

The vasculotropic E22Q mutant of the amyloid-beta (A beta) peptide is associated with hereditary cerebral hemorrhage with amyloidosis Dutch type. The cellular mechanism(s) of toxicity and nature of the A beta E22Q toxic assemblies are not completely understood. Comparative assessment of structural parameters and cell death mechanisms elicited in primary human cerebral endothelial cells by A beta E22Q and wild-t...


MODULATION OF MIRNAS BY BILE ACIDS

Castro, R. E.; Zeng, Y.; Steer, C. J.; Kren, B. T.; Rodrigues, C. M. P.



Role of miR-21 in regenerating rat liver

Castro, R. E.; Santos, D. M.; Zeng, Y.; Steer, C. J.; Rodrigues, C. M.; Kren, B. T.



Differential regulation of cyclin D1 and apoptosis by bile acids in primary rat...

Castro, R. E.; Amaral, J. D.; Sola, S.; Kren, B. T.; Steer, C. J.; Rodrigues, C. M.


P53 is a specific molecular target of ursodeoxycholic acid

Amaral, J. D.; Castro, R. E.; Sola, S.; Rodrigues, C. M.


Progesterone and caspase-3 activation in equine cyclic corpora lutea

Ferreira-Dias, G.; Mateus, L.; Costa, A. S.; Sola, S.; Ramalho, R. M.; Castro, R. E.; Rodrigues, C. M. P.

Soon after ovulation, the newly formed corpus luteum (CL) starts secreting progesterone (P-4), necessary for implantation. The CL, an ovarian transient endocrine organ, undergoes growth and regression throughout its life span. The objective of this study


Bile acids differentally regulate cell cycle and apoptosis-related proteins in ...

Castro, R. E.; Amaral, J. D.; Borralho, P.; Sola, S.; Kren, B. T.; Steer, C. J.; Rodrigues, C. M. P.



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