26 documents found, page 1 of 3
Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomark...
Marques, V; Afonso, MB; Bierig, N; Duarte-Ramos, F; Santos-Laso, Á; Jimenez-Agüero, R; Eizaguirre, E; Bujanda, L; Pareja, MJ; Luís, R; Costa, ABackground: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease where liver biopsy remains the gold standard for diagnosis. Here we aimed to evaluate the role of circulating adiponectin, leptin, and insulin-like growth factor 1 (IGF-1) levels as non-invasive NAFLD biomarkers and assess their correlation with the metabolome. Materials and Methods: Leptin, adiponectin, and IGF-1 seru...
Molecular and Cell Biology of Eukaryotic Systems
Rodrigues, CMP; Gama, MJ; Moreira da Silva, IB; Rodrigues, E; Solá, S; Castro-Caldas, M; Castro, RE; Ramalho, RM; Nunes, AF; Amaral, JD; Borralho, PM
Nuclear steroid receptors modulate cellular trafficking of ursodeoxycholic acid...
Sola, S; Amaral, JD; Castro, RE; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CMP
Nuclear translocation of UDCA by the glucocorticoid receptor is required to red...
Sola, S; Amaral, J; Castro, RE; Ramalho, RM; Borralho, PM; Kren, BT; Tanaka, H; Steer, CJ; Rodrigues, CMPUrsodeoxycholic acid (UDCA) inhibits classical mitochondrial pathways of apoptosis by either directly stabiliz* mitochondrial membranes or modulating specific upstream targets. Furthermore, UDCA regulates apoptosis-related genes from transforming growth f
Modulation of neurotoxicity associated with Alzheimer's disease-linked amyloid ...
Ramalho, RM; Borralho, PM; Sola, S; Castro, RE; Amaral, JD; Rodrigues, CMP
Ursodeoxycholic acid modulates cell cycle proteins that control apoptosis of pr...
Castro, RE; Amaral, JD; Kren, BT; Steer, CJ; Rodrigues, CMP
Increased apoptosis and decreased p53 and Bax expression in colorectal tumours
Borralho, PM; Ravasco, P; da Silva, IBM; Castro, RE; Ramalho, RM; Sola, S; Correia, L; Fernandes, A; Camilo, ME; Rodrigues, CMP
5-Fluorouracil differentially modulates apoptosis of colorectal cancer cells
da Silva, IBM; Borralho, PM; Castro, RE; Ramalho, RM; Albuquerque, C; Laitao, CN; Rodrigues, CMP
A distinct microarray gene expression profile in primary rat hepatocytes incuba...
Castro, RE; Sola, S; Ma, XM; Ramalho, RM; Kren, BT; Steer, CJ; Rodrigues, CMPBackground/Aims: Ursodeoxycholic acid (UDCA) and its taurine-conjugated derivative, TUDCA, modulate cell death and cell cycle regulators, such as E2F-1 and p53. However, precise pathways underlying UDCA's effects are not fully understood. The aim of this
Nuclear translocation of UDCA via the glucocorticoid receptor is essential for ...
Sola, S; Amaral, JD; Castro, RE; Ramalho, RM; Borralho, PM; Kren, BT; Steer, C; Rodrigues, CM