5 documents found, page 1 of 1
Peptides ToAP3 and ToAP4 decrease release of inflammatory cytokines through TLR...
Veloso Júnior, Paulo Henrique de Holanda; Simon, Karina Smidt; Castro, Raffael Júnio Araújo de; Coelho, Luísa Coutinho; Hurtado Erazo, Fabián AndresAntimicrobial peptides (AMPs) are small molecules with microbicidal and immunoregulatory activities. In this study we evaluated the anti-inflammatory and antimicrobial activities of peptides ToAP3 and ToAP4, AMPs from the venom of the Brazilian scorpion Tityus obscurus. To test the peptides’ activity, murine bone marrow-derived macrophages (BMDMs) or dendritic cells (BMDCs) were stimulated with peptides plus LP...
Early immune response against Fonsecaea pedrosoi requires Dectin-2-mediated Th1...
Siqueira, Isaque Medeiros; Wüthrich, Marcel; Li, Mengyi; Wang, Huafeng; Las-Casas, Lucas de Oliveira; Castro, Raffael Júnio Araújo de; Klein, BruceChromoblastomycosis (CBM) is a chronic worldwide subcutaneous mycosis, caused by several dimorphic, pigmented dematiaceous fungi. It is difficult to treat patients with the disease, mainly because of its recalcitrant nature. The correct activation of host immune response is critical to avoid fungal persistence in the tissue and disease chronification. CD4+ T cells are crucial for the development of protective i...
Investigação de potenciais sítios reservatórios para a infecção criptocócica la...
Castro, Raffael Júnio Araújo deTese (doutorado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, Programa de Pós-Graduação em Biologia Molecular, 2020.; CNPq - FAP-DF; Uma característica marcante da criptococose, doença causada pelo fungo Cryptococcus neoformans (Cn), é o estabelecimento de uma infecção latente, normalmente em granulomas pulmonares. Não obstante, acredita-se na existência de outro...
Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the cour...
Siqueira, Isaque Medeiros; Castro, Raffael Júnio Araújo de; Leonhardt, Luiza Chaves de Miranda; Jerônimo, Márcio Sousa; Soares, Aluízio CarlosA common theme across multiple fungal pathogens is their ability to impair the establishment of a protective immune response. Although early inflammation is beneficial in containing the infection, an uncontrolled inflammatory response is detrimental and may eventually oppose disease eradication. Chromoblastomycosis (CBM), a cutaneous and subcutaneous mycosis, caused by dematiaceous fungi, is capable of inducing...
O papel do inflamassoma na infecção induzida pelas formas saprofíticas do fungo...
Castro, Raffael Júnio Araújo deDissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2016.; O Fonsecaea pedrosoi é um fungo dimórfico e o principal agente etiológico da cromoblastomicose, infecção crônica da pele e tecidos subcutâneos iniciada pela inoculação transcutânea das formas saprofíticas do fungo. No hospedeiro, essas células transformam-se em células muriformes, tid...