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Population homogeneity for the antibody response to COVID-19 BNT162b2/Comirnaty...
Faro-Viana, João; Bergman, Marie-Louise; Gonçalves, Lígia A.; Duarte, Nadia; Coutinho, Teresa P.; Borges, Patricia C.; Diwo, Christian; Castro, RuteABSTRACT: While mRNA vaccines are administrated worldwide in an effort to contain the COVID-19 pandemic, the heterogeneity of the humoral immune response they induce at the population scale remains unclear. Here, in a prospective, longitudinal, cohort-study, including 1245 hospital care workers and 146 nursing home residents scheduled for BNT162b2 vaccination, together covering adult ages from 19 to 99 years, w...
High-resolution structure of an atypical α-phosphoglucomutase related to eukary...
Nogly, Przemyslaw; Matias, Pedro M.; de Rosa, Matteo; Castro, Rute; Santos, Helena; Neves, Ana Rute; Archer, MargaridaThe first structure of a bacterial α-phosphoglucomutase with an overall fold similar to eukaryotic phosphomannomutases is reported. Unlike most α-phosphoglucomutases within the α-D-phosphohexomutase superfamily, it belongs to subclass IIb of the haloacid dehalogenase superfamily (HADSF). It catalyzes the reversible conversion of α-glucose 1-phosphate to glucose 6-phosphate. The crystal structure of α-phosphoglu...