3 documents found, page 1 of 1
Sodium salicylate prevents paraquat-induced apoptosis in the rat lung
Dinis Oliveira, RJ; Sousa, C; Remiao, F; Duarte, JA; Ferreira, R; Sanchez S Navarro; Bastos, ML; Carvalho, FThe nonselective contact herbicide, paraquat (PQ), is a strong pneumotoxicant, especially due to its accumulation in the lung through a polyamine uptake system and to its capacity to induce redox cycling, leading to oxidative stress-related damage. In the present study, we aimed to investigate the occurrence of apoptotic events in the lungs of male Wistar rats, 24, 48, and 96 h after PQ exposure (25 mg/kg ip) a...
P-glycoprotein induction: an antidotal pathway for paraquat-induced lung toxicity
Dinis Oliveira, RJ; Remiao, F; Duarte, JA; Ferreira, R; Sanchez S Navarro; Bastos, ML; Carvalho, FThe widespread use of the nonselective contact herbicide paraquat (PQ) has been the cause of thousands of deaths from both accidental and voluntary ingestion. The main target organ for PQ toxicity is the lung. No antidote or effective treatment to decrease PQ accumulation in the lung or to disrupt its toxicity has yet been developed. The present study describes a procedure that leads to a remarkable decrease in...
d-Amphetamine-induced hepatoxicity: Possible contribution of catecholamines and...
Carvalho, F; Remiao, F; Soares, ME; Catarino, R; Queiroz, G; Bastos, MLAmphetamines are indirect-acting sympathomimetic drugs widely abused due to their physical and psychostimulating effects. However, the use of these drugs has been associated with numerous reports of hepatotoxicity. While glutathione depletion induced by amphetamines contributes to the exposure of hepatocytes to oxidative damage, other indirect effects attributed to amphetamines may have a role in cell injury. T...