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Exogenous surfactant prevents hyperoxiainduced lung injury in adult mice.

Bezerra, Frank Silva; Ramos, Camila de Oliveira; Castro, Thalles de Freitas; Araújo, Natália Pereira da Silva; Souza, Ana Beatriz Farias de

Background: In addition to the risk of developing ventilator-induced lung injury, patients with ARDS are at risk of developing hyperoxic injury due the supra-physiological oxygen supplementation clinically required to reverse hypoxemia. Alterations of endogenous surfactant system participate in the pulmonary dysfunction observed in ARDS. Administration of exogenous surfactant could have protective effects durin...

Date: 2020   |   Origin: Oasisbr

Mayaro virus induction of oxidative stress is associated with liver pathology i...

Caetano, Camila Carla da Silva; Camini, Fernanda Caetano; Almeida, Letícia Trindade; Ferraz, Ariane Coelho; Silva, Tales Fernando da

Mayaro virus (MAYV) causes Mayaro fever in humans, a self-limiting acute disease, with persistent arthralgia and arthritis. Although MAYV has a remerging potential, its pathogenic mechanisms remain unclear. Here, we characterized a model of MAYV infection in 3–4-week BALB/c mice. We investigated whether the liver acts as a site of viral replication and if the infection could cause histopathological alterations ...

Date: 2020   |   Origin: Oasisbr

Efeito do consumo da polpa de açaí (Euterpe Oleracea Mart.) sobre biomarcadores...

Castro, Thalles de Freitas

Programa de Pós-Graduação em Saúde e Nutrição. Escola de Nutrição, Universidade Federal de Ouro Preto.; A obesidade é uma doença multifatorial dependente de determinantes genéticos e disfunções endócrinas, relacionada, a um processo inflamatório de baixo grau. Efetivamente, o aumento dos estoques de gordura corporal observado na obesidade está associado a complicações metabólicas podendo induzir uma elevação na...

Date: 2018   |   Origin: Oasisbr

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