7 documents found, page 1 of 1
Oral Ang-(1-7) treatment improves white adipose tissue remodeling and hypertens...
Barbosa, Maria Andréa; Sousa, Graziele Galdino de; Castro, Uberdan Guilherme Mendes de; Carneiro, Cláudia Martins; Figueiredo, Vivian PaulinoObjective: Angiotensin (Ang)-(1-7) has preventive effects on metabolic syndrome (MetS). The aim of this study was to evaluate the therapeutic effect of oral Ang-(1-7) on mean arterial pressure (MAP), insulin resistance (IR), inflammatory process, and remodeling of white adipose tissue (WAT) in rats with establishedMetS. Methods: Rats were subjected to control (CT; AIN-93M) or high-fat (HF) diets for 13 wk to in...
Antioxidant effects of oral Ang-(1-7) restore insulin pathway and RAS component...
Figueiredo, Vivian Paulino; Barbosa, Maria Andréa; Castro, Uberdan Guilherme Mendes de; Zacarias, Aline Cruz; Bezerra, Frank SilvaIn prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling. We evaluated the HPβCD/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS. After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated...
Tratamento com hpβcd/ang-(1-7) reverte distúrbios da síndrome metabólica atravé...
Castro, Uberdan Guilherme Mendes dePrograma de Pós-Graduação em Ciências Biológicas. Núcleo de Pesquisas em Ciências Biológicas, Pró-Reitoria de Pesquisa de Pós Graduação, Universidade Federal de Ouro Preto.; O objetivo do presente estudo foi avaliar o potencial terapêutico da formulação oral de Ang-(1-7), a HPβCD/Ang-(1-7), sobre o processo inflamatório do tecido adiposo branco visceral (TAV) e tecido adiposo marrom (TAM), sobre as vias de sina...
Nitric oxide at the CVLM is involved in the attenuation of the reflex bradycard...
Castro, Uberdan Guilherme Mendes de; Souza, Graziele Galdino de; Machado, Raquel do Pilar; Isoldi, Mauro César; Silva, Marcelo EustáquioHypertension is associated to an increase in central oxidative stress and an attenuation of the baroreflex control of arterial pressure. The present study evaluated the effect of alterations in the levels of nitric oxide (NO) and superoxide anion in the caudal ventrolateral medulla (CVLM), a key area of the brainstem for the baroreflex control of arterial pressure, in renovascular hypertensive rats (2K1C). Base...
Age-dependent effect of high-fructose and high-fat diets on lipid metabolism an...
Castro, Uberdan Guilherme Mendes de; Santos, Robson Augusto Souza dos; Silva, Marcelo Eustáquio; Lima, Wanderson Geraldo deBackground: The metabolic syndrome (MS) is characterized by variable coexistence of metabolic and pathophysiological alterations which are important risk factors for developing of type II diabetes and/or cardiovascular diseases. Increased of MS patients in worldwide has stimulated the development of experimental models. However, it is still challenging to find an dietetic model that most closely approximates hu...
Efeito do óxido nítrico na regulação de parâmetros cardiovasculares pela CVLM e...
Castro, Uberdan Guilherme Mendes deA hipertensão arterial pode ocorrer devido à hiperatividade de neurônios do bulbo ventrolateral rostral (RVLM) (Chan e cols., 1991; Boone e McMillen, 1994; Suzuki e cols., 1994; Minson e cols., 1996) e/ou devido a um tônus reduzido dos neurônios GABAérgicos do bulbo ventrolateral caudal (CVLM) que se projetam para a RVLM. (Smith e Barron, 1990b; a; Colombari e cols., 2001). Além disso, foi observado que durante...
Angiotensin-(1-7) antagonist, A-779, microinjection into the caudal ventrolater...
Cangussu, Luiza Michelle; Castro, Uberdan Guilherme Mendes de; Machado, Raquel do Pilar; Silva, Marcelo Eustáquio; Ferreira, Patrícia MariaIn the present study we evaluated the effect of caudal ventrolateral medulla (CVLM) microinjection of the main angiotensin (Ang) peptides, Ang II and Ang-(1-7), and their selective antagonists on baseline arterial pressure (AP) and on baroreceptor-mediated bradycardia in renovascular hypertensive rats (2K1C). Microinjection of Ang II and Ang-(1-7) into the CVLM of 2K1C rats produced similar decrease in AP as ob...